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We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.","is_dataset_classified":null,"base_score":6.733401891837359,"endowment":6.733401891837359,"datacite_reuse_total":24,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35296864","pmcid":"PMC9504827","openalex_id":"https://openalex.org/W4221010612","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK057521","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"K08 HG010155","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK087092","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK102173","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK046200","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"F32 DK124914","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"T32 DK007516","title":null},{"funder_name":"Lundbeck Foundation","grant_id":"R190-2014-3904","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"U01 HG011719","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"RC2 DK116691","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"UM1 DK126185","title":null},{"funder_name":"National Institutes of Health","grant_id":"3RC2DK116691-03S1","title":"Generation of a Cellular Atlas of Adipose Tissue in Mouse and Man"},{"funder_name":"National Institutes of Health","grant_id":"1P30DK046200-01","title":"OBESITY/NUTRITION RESEARCH CENTER"},{"funder_name":"National Institutes of Health","grant_id":"5R01DK102173-03","title":"A Causal Role for Nuclear Receptor Pathways in Insulin Resistance"},{"funder_name":"National Institutes of Health","grant_id":"5P30DK057521-09","title":"CORE--RADIOIMMUNOASSAY/MONOCLONAL ANTIBODIES"},{"funder_name":"National Institutes of Health","grant_id":"5F32DK124914-02","title":"Investigating the Regulation of IRF4 in Adipocytes"},{"funder_name":"National Institutes of Health","grant_id":"5UM1DK126185-05","title":"Bridging the gap between type 2 diabetes GWAS and therapeutic targets"},{"funder_name":"National Institutes of Health","grant_id":"5U01HG011719-03","title":"Enabling improved applicability and transferability of polygenic scores across diverse populations- a focus on South Asians"},{"funder_name":"National Institutes of Health","grant_id":"1K08HG010155-01","title":"Polygenic prediction of common, complex diseases"}],"total_grants":19,"fwci":104.4235,"citation_percentile":0.99983099,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":73},{"year":2023,"count":183},{"year":2024,"count":225},{"year":2025,"count":230},{"year":2026,"count":127}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9504827","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9504827","host_type":"repository"},{"url":"https://www.nature.com/articles/s41586-022-04518-2.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41586-022-04518-2","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41586-022-04518-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35296864","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/d0fb60a7-7bb3-46f6-8f1f-caab676a7e81","host_type":"repository"},{"url":"https://doi.org/10.1101/2021.11.09.466968","host_type":""},{"url":"https://www.biorxiv.org/content/biorxiv/early/2021/11/11/2021.11.09.466968.full.pdf","host_type":""},{"url":"https://doi.org/10.1530/ey.20.9.2","host_type":""},{"url":"https://dx.doi.org/10.1101/2021.11.09.466968","host_type":""},{"url":"https://curis.ku.dk/ws/files/300907932/2021.11.09.466968v1.full.pdf","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/s41586-022-04518-2","host_type":""}],"fields_of_study":["Adipokines, Inflammation, and Metabolic Diseases","Adipose Tissue and Metabolism","Atherosclerosis and Cardiovascular Diseases","0301 basic medicine","03 medical and health sciences","Adipose Tissue","Adipose Tissue, White","Adiposity","Animals","Atlases as Topic","Diabetes Mellitus, Type 2","Humans","Insulin Resistance","Metabolic Diseases","Mice","Obesity"],"mesh_terms":["Adipose Tissue","Animals","Atlases as Topic","Diabetes Mellitus, Type 2","Humans","Insulin Resistance","Metabolic Diseases","Obesity","Adiposity","Mice","Adipose Tissue, White"],"keywords":["Atlas (anatomy)","Adipose tissue","White adipose tissue","White (mutation)","Cell","Biology","Anatomy","Genetics","Endocrinology","Gene","Adipose Tissue, White","Mice","Atlases as Topic","Diabetes Mellitus, Type 2","Metabolic Diseases","Animals","Humans","Obesity","Insulin Resistance","Adiposity"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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