{"doi":"10.1038/s41586-020-2012-7","title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","abstract":"Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats<sup>1-4</sup>. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans<sup>5-7</sup>. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.","journal":"Nature","year":2020,"id":1501,"datarank":34.76256392496132,"base_score":10.054060411015502,"endowment":10.054060411015502,"self_citation_contribution":1.5081090616523256,"citation_network_contribution":33.25445486330899,"self_endowment_contribution":1.5081090616523256,"citer_contribution":33.25445486330899,"corpus_percentile":99.8,"corpus_rank":325,"citation_count":23249,"citer_count":195,"citers_with_citation_signal":195,"citers_with_endowment":195,"datacite_reuse_total":0,"is_dataset":false,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-02-03","authors":[{"id":17690,"name":"Xing-Lou Yang","orcid":null,"position":1,"is_corresponding":false},{"id":17691,"name":"Xian-Guang Wang","orcid":null,"position":2,"is_corresponding":false},{"id":17692,"name":"Ben Hu","orcid":"0000-0001-9194-3474","position":3,"is_corresponding":false},{"id":17693,"name":"Lei Zhang","orcid":"0000-0003-4921-8986","position":4,"is_corresponding":false},{"id":1357,"name":"Wei Zhang","orcid":"0000-0002-0942-1245","position":5,"is_corresponding":false},{"id":17694,"name":"Hao-Rui Si","orcid":null,"position":6,"is_corresponding":false},{"id":17695,"name":"Yan Zhu","orcid":"0000-0002-7045-4847","position":7,"is_corresponding":false},{"id":17696,"name":"Bei Li","orcid":"0009-0007-6702-4276","position":8,"is_corresponding":false},{"id":17697,"name":"Chao-Lin Huang","orcid":null,"position":9,"is_corresponding":false},{"id":17698,"name":"Hui-Dong Chen","orcid":null,"position":10,"is_corresponding":false},{"id":17699,"name":"Jing Chen","orcid":"0000-0001-5972-3623","position":11,"is_corresponding":false},{"id":17700,"name":"Yun Luo","orcid":"0000-0002-6243-7000","position":12,"is_corresponding":false},{"id":17701,"name":"Hua Guo","orcid":"0000-0003-4388-6465","position":13,"is_corresponding":false},{"id":17702,"name":"Ren-Di Jiang","orcid":"0000-0003-4235-6964","position":14,"is_corresponding":false},{"id":17703,"name":"Mei-Qin Liu","orcid":null,"position":15,"is_corresponding":false},{"id":17704,"name":"Ying Chen","orcid":"0000-0001-8306-8083","position":16,"is_corresponding":false},{"id":17705,"name":"Xu-Rui Shen","orcid":null,"position":17,"is_corresponding":false},{"id":17706,"name":"Xi Wang","orcid":"0000-0002-4660-9562","position":18,"is_corresponding":false},{"id":17707,"name":"Xiao-Shuang Zheng","orcid":null,"position":19,"is_corresponding":false},{"id":17708,"name":"Kai Zhao","orcid":"0000-0003-0468-2128","position":20,"is_corresponding":false},{"id":17709,"name":"Quan-Jiao Chen","orcid":null,"position":21,"is_corresponding":false},{"id":12876,"name":"Heping Zhang","orcid":"0000-0002-0688-4076","position":22,"is_corresponding":false},{"id":17711,"name":"Lin-Lin Liu","orcid":null,"position":23,"is_corresponding":false},{"id":17712,"name":"Bing Yan","orcid":"0000-0002-7970-6764","position":24,"is_corresponding":false},{"id":17713,"name":"Fa-Xian Zhan","orcid":null,"position":25,"is_corresponding":false},{"id":17714,"name":"Yan-Yi Wang","orcid":null,"position":26,"is_corresponding":false},{"id":17715,"name":"Geng-Fu Xiao","orcid":null,"position":27,"is_corresponding":false},{"id":17716,"name":"Zheng-Li Shi","orcid":null,"position":28,"is_corresponding":false},{"id":17717,"name":"Xing‐Lou Yang","orcid":"0000-0002-5317-8983","position":29,"is_corresponding":false},{"id":17718,"name":"Huidong Chen","orcid":"0000-0001-7676-6350","position":30,"is_corresponding":false},{"id":12877,"name":"Fēi Dèng","orcid":"0000-0002-5385-083X","position":31,"is_corresponding":false},{"id":17719,"name":"Linlin Liu","orcid":"0000-0001-5093-7940","position":32,"is_corresponding":false},{"id":17720,"name":"Yanyi Wang","orcid":"0000-0003-0192-1891","position":33,"is_corresponding":false},{"id":17721,"name":"Gengfu Xiao","orcid":null,"position":34,"is_corresponding":false},{"id":17722,"name":"Zheng‐Li Shi","orcid":"0000-0001-8089-163X","position":35,"is_corresponding":false},{"id":17689,"name":"Peng Zhou","orcid":"0000-0001-9863-4201","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}