{"doi":"10.1038/s41577-023-00941-2","title":"Immunological factors linked to geographical variation in vaccine responses","abstract":null,"journal":"Nature Reviews Immunology","year":2024,"id":631342,"datarank":0.6681520944380261,"base_score":4.454347296253507,"endowment":4.454347296253507,"self_citation_contribution":0.6681520944380261,"citation_network_contribution":0.0,"self_endowment_contribution":0.6681520944380261,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1636061,"name":"Jeremia J. Pyuza","orcid":null,"position":1,"is_corresponding":false},{"id":1150020,"name":"Gyaviira Nkurunungi","orcid":"0000-0003-4062-9105","position":2,"is_corresponding":false},{"id":1636062,"name":"Vesla I. Kullaya","orcid":null,"position":3,"is_corresponding":false},{"id":772567,"name":"Hermelijn H. Smits","orcid":"0000-0001-9279-2890","position":4,"is_corresponding":false},{"id":488920,"name":"Pancras C.W. Hogendoorn","orcid":"0000-0002-1513-8104","position":5,"is_corresponding":false},{"id":1412836,"name":"Linda J. Wammes","orcid":"0000-0002-6660-9738","position":6,"is_corresponding":false},{"id":1314838,"name":"Bart Everts","orcid":"0000-0002-3764-5131","position":7,"is_corresponding":false},{"id":454873,"name":"Alison M. Elliott","orcid":"0000-0003-2818-9549","position":8,"is_corresponding":false},{"id":1300510,"name":"Simon P. Jochems","orcid":"0000-0002-4835-1032","position":9,"is_corresponding":false},{"id":608900,"name":"Maria Yazdanbakhsh","orcid":"0000-0002-7666-1441","position":10,"is_corresponding":false},{"id":1636060,"name":"Marloes M. A. R. van Dorst","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immunological factors linked to geographical variation in vaccine responses","abstract":"Vaccination is one of medicine's greatest achievements; however, its full potential is hampered by considerable variation in efficacy across populations and geographical regions. For example, attenuated malaria vaccines in high-income countries confer almost 100% protection, whereas in low-income regions these same vaccines achieve only 20-50% protection. This trend is also observed for other vaccines, such as bacillus Calmette-Guérin (BCG), rotavirus and yellow fever vaccines, in terms of either immunogenicity or efficacy. Multiple environmental factors affect vaccine responses, including pathogen exposure, microbiota composition and dietary nutrients. However, there has been variable success with interventions that target these individual factors, highlighting the need for a better understanding of their downstream immunological mechanisms to develop new ways of modulating vaccine responses. Here, we review the immunological factors that underlie geographical variation in vaccine responses. Through the identification of causal pathways that link environmental influences to vaccine responsiveness, it might become possible to devise modulatory compounds that can complement vaccines for better outcomes in regions where they are needed most.","is_dataset_classified":null,"base_score":4.454347296253507,"endowment":4.454347296253507,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37770632","pmcid":null,"openalex_id":"https://openalex.org/W4387130384","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MR/K019708/1","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_UU_00027/5","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_UU_00033/2","title":null},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"}],"total_grants":4,"fwci":14.3164,"citation_percentile":0.99454579,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":21},{"year":2025,"count":42},{"year":2026,"count":21}],"oa_status":"green","license":"Springer Nature TDM","oa_locations":[{"url":"https://scholarlypublications.universiteitleiden.nl/access/item%3A3643519/view","host_type":"repository"},{"url":"https://scholarlypublications.universiteitleiden.nl/access/item%3A3643519/view","host_type":"repository"},{"url":"https://www.nature.com/articles/s41577-023-00941-2.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41577-023-00941-2","host_type":"publisher"},{"url":"https://hdl.handle.net/1887/3643518","host_type":"repository"},{"url":"https://doi.org/10.1038/s41577-023-00941-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37770632","host_type":"repository"},{"url":"https://biblio.vub.ac.be/vubir/immunological-factors-linked-to-geographical-variation-in-vaccine-responses(94135f2f-468e-4e2d-b27f-7054f11ab743).html","host_type":"repository"},{"url":"http://dx.doi.org/10.1038/s41577-023-00941-2","host_type":""}],"fields_of_study":["Viral gastroenteritis research and epidemiology","SARS-CoV-2 and COVID-19 Research","Vaccine Coverage and Hesitancy","Medicine","Environmental Science","Biology","Humans","BCG Vaccine","Vaccination","Immunologic Factors","Vaccines, Attenuated"],"mesh_terms":["BCG Vaccine","Humans","Immunologic Factors","Vaccination","Vaccines, Attenuated"],"keywords":["Vaccination","Immunogenicity","Malaria","Immunology","Biology","Vaccine efficacy","Environmental health","Immune system","Medicine","BCG Vaccine","Humans","Immunologic Factors","Vaccines, Attenuated"],"sdg_mappings":[{"sdg_number":1,"sdg_label":"1. No poverty"},{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T23:23:58.237860Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}