{"doi":"10.1038/s41564-024-01784-w","title":"The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis","abstract":null,"journal":"Nature Microbiology","year":2024,"id":612359,"datarank":0.6698862177981877,"base_score":4.465908118654584,"endowment":4.465908118654584,"self_citation_contribution":0.6698862177981877,"citation_network_contribution":0.0,"self_endowment_contribution":0.6698862177981877,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1576661,"name":"Xiao-Xu Leng","orcid":null,"position":1,"is_corresponding":false},{"id":1576662,"name":"Jianxun Qi","orcid":null,"position":2,"is_corresponding":false},{"id":1030609,"name":"Ni Wang","orcid":"0000-0002-1796-7803","position":3,"is_corresponding":false},{"id":86910,"name":"Ji‐Xuan Han","orcid":"0000-0002-3983-1747","position":4,"is_corresponding":false},{"id":1576663,"name":"Zhi-Hang Tao","orcid":"0009-0000-9720-519X","position":5,"is_corresponding":false},{"id":1576664,"name":"Zi-Yan Zhuang","orcid":null,"position":6,"is_corresponding":false},{"id":1576665,"name":"Yimeng Ren","orcid":null,"position":7,"is_corresponding":false},{"id":1576666,"name":"Yi-Le Xie","orcid":null,"position":8,"is_corresponding":false},{"id":1576667,"name":"Shan-Shan Jiang","orcid":null,"position":9,"is_corresponding":false},{"id":1576668,"name":"Jia-Lu Li","orcid":null,"position":10,"is_corresponding":false},{"id":1488714,"name":"Huimin Chen","orcid":"0000-0002-2079-873X","position":11,"is_corresponding":false},{"id":1576669,"name":"Cheng-Bei Zhou","orcid":null,"position":12,"is_corresponding":false},{"id":857555,"name":"Yun Cui","orcid":"0000-0003-1688-3744","position":13,"is_corresponding":false},{"id":413880,"name":"Xiaoyu Chen","orcid":"0000-0003-1080-1832","position":14,"is_corresponding":false},{"id":268819,"name":"Zheng Wang","orcid":"0000-0001-7138-8581","position":15,"is_corresponding":false},{"id":1576670,"name":"Zi-Zhen Zhang","orcid":null,"position":16,"is_corresponding":false},{"id":86906,"name":"Jie Hong","orcid":"0000-0001-9579-0794","position":17,"is_corresponding":false},{"id":630584,"name":"Haoyan Chen","orcid":"0000-0001-6722-8534","position":18,"is_corresponding":false},{"id":301466,"name":"Weihong Jiang","orcid":"0000-0002-2866-5675","position":19,"is_corresponding":false},{"id":86904,"name":"Yingxuan Chen","orcid":"0000-0002-1883-7736","position":20,"is_corresponding":false},{"id":91813,"name":"Xin Zhao","orcid":"0000-0002-1748-2275","position":21,"is_corresponding":false},{"id":13179,"name":"Jun Yu","orcid":"0000-0001-5008-2153","position":22,"is_corresponding":false},{"id":86911,"name":"Jing‐Yuan Fang","orcid":"0000-0003-2282-0248","position":23,"is_corresponding":false},{"id":1128466,"name":"Lu Zhang","orcid":"0000-0001-8358-6112","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis","abstract":"Fusobacterium nucleatum can bind to host cells and potentiate intestinal tumorigenesis. Here we used a genome-wide screen to identify an adhesin, RadD, which facilitates the attachment of F. nucleatum to colorectal cancer (CRC) cells in vitro. RadD directly binds to CD147, a receptor overexpressed on CRC cell surfaces, which initiated a PI3K-AKT-NF-κB-MMP9 cascade, subsequently enhancing tumorigenesis in mice. Clinical specimen analysis showed that elevated radD gene levels in CRC tissues correlated positively with activated oncogenic signalling and poor patient outcomes. Finally, blockade of the interaction between RadD and CD147 in mice effectively impaired F. nucleatum attachment and attenuated F. nucleatum-induced oncogenic response. Together, our study provides insights into an oncogenic mechanism driven by F. nucleatum RadD and suggests that the RadD-CD147 interaction could be a potential therapeutic target for CRC.","is_dataset_classified":null,"base_score":4.454347296253507,"endowment":4.454347296253507,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39169124","pmcid":null,"openalex_id":"https://openalex.org/W4401758323","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China (National Science Foundation of China)","grant_id":"82250005","title":null},{"funder_name":"Shanghai Science and Technology Development Foundation (Shanghai Science and Technology Development Fund)","grant_id":"20JC1410100","title":null},{"funder_name":"National Natural Science Foundation of China (National Science Foundation of China)","grant_id":"82203227","title":null},{"funder_name":"National Natural Science Foundation of China (National Science Foundation of China)","grant_id":"32100138","title":null},{"funder_name":"National Natural Science Foundation of China (National Science Foundation of China)","grant_id":"82330086","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"2022M712128","title":null},{"funder_name":"National Natural Science Foundation of China (National Science Foundation of China)","grant_id":"81830081","title":null}],"total_grants":7,"fwci":13.7497,"citation_percentile":0.99469738,"influential_citations":0,"citation_trend":[{"year":2024,"count":5},{"year":2025,"count":48},{"year":2026,"count":32}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://www.nature.com/articles/s41564-024-01784-w.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41564-024-01784-w","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41564-024-01784-w","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39169124","host_type":"repository"}],"fields_of_study":["Gut microbiota and health","Infections and bacterial resistance","Salivary Gland Tumors Diagnosis and Treatment","Fusobacterium nucleatum","Colorectal Neoplasms","Animals","Humans","Mice","Basigin","Adhesins, Bacterial","Carcinogenesis","Bacterial Adhesion","Cell Line, Tumor","Fusobacterium Infections","Matrix Metalloproteinase 9","Signal Transduction","NF-kappa B","Phosphatidylinositol 3-Kinases","Female"],"mesh_terms":["Animals","Bacterial Adhesion","Female","Fusobacterium Infections","Humans","Colorectal Neoplasms","Signal Transduction","NF-kappa B","Fusobacterium nucleatum","Adhesins, Bacterial","Phosphatidylinositol 3-Kinases","Matrix Metalloproteinase 9","Cell Line, Tumor","Mice","Basigin","Carcinogenesis"],"keywords":["Fusobacterium nucleatum","Bacterial adhesin","Colorectal cancer","Colonization","Carcinogenesis","Fusobacterium","Microbiology","Cancer research","Medicine","Biology","Cancer","Bacteria","Gene","Internal medicine","Porphyromonas gingivalis","Genetics","Escherichia coli","Bacteroides"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T03:03:23.441350Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}