{"doi":"10.1038/s41564-024-01613-0","title":"Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice","abstract":"Abstract In sub-Saharan Africa, multidrug-resistant non-typhoidal Salmonella serovars are a common cause of fatal bloodstream infection. Malnutrition is a predisposing factor, but the underlying mechanisms are unknown. Here we show that vitamin A deficiency, one of the most prevalent micronutrient deficits afflicting African children, increases susceptibility to disseminated non-typhoidal Salmonella disease in mice and impairs terminal neutrophil maturation. Immature neutrophils had reduced expression of Slc11a1 , a gene that encodes a metal ion transporter generally thought to restrict pathogen growth in macrophages. Adoptive transfer of SLC11A1-proficient neutrophils, but not SLC11A1-deficient neutrophils, reduced systemic Salmonella burden in Slc11a1 −/− mice or mice with vitamin A deficiency. Loss of terminal granulopoiesis regulator CCAAT/enhancer-binding protein ϵ (C/EBPϵ) also decreased neutrophil-mediated control of Salmonella , but not that mediated by peritoneal macrophages. Susceptibility to infection increased in Cebpe −/− Slc11a1 +/+ mice compared with wild-type controls, in an Slc11a1 -expression-dependent manner. These data suggest that SLC11A1 deficiency impairs Salmonella control in part by blunting neutrophil-mediated defence.","journal":"Nature Microbiology","year":2024,"id":425381,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":530466,"name":"Vladimir E. Diaz-Ochoa","orcid":"0000-0001-5393-418X","position":1,"is_corresponding":false},{"id":1223471,"name":"Lizbeth Camacho","orcid":null,"position":2,"is_corresponding":false},{"id":530464,"name":"Annica R. Stull-Lane","orcid":"0000-0003-1602-910X","position":3,"is_corresponding":false},{"id":1223472,"name":"Amber E. R. Van Hecke","orcid":null,"position":4,"is_corresponding":false},{"id":1223035,"name":"Jason P. Mooney","orcid":"0000-0002-2824-124X","position":5,"is_corresponding":false},{"id":531161,"name":"Ariel Del Hoyo Muñoz","orcid":null,"position":6,"is_corresponding":false},{"id":530467,"name":"G. Walker","orcid":"0000-0002-3888-8143","position":7,"is_corresponding":false},{"id":426672,"name":"Daniela Hampel","orcid":"0000-0003-0288-7680","position":8,"is_corresponding":false},{"id":873747,"name":"Xiaowen Jiang","orcid":"0000-0003-1618-4265","position":9,"is_corresponding":false},{"id":366397,"name":"Jasmine C. Labuda","orcid":"0000-0001-6078-5733","position":10,"is_corresponding":false},{"id":900637,"name":"Claire E. Depew","orcid":"0000-0002-9341-9286","position":11,"is_corresponding":false},{"id":366401,"name":"Stephen J. McSorley","orcid":"0000-0002-6363-3222","position":12,"is_corresponding":false},{"id":235511,"name":"Charles B. Stephensen","orcid":"0000-0002-2117-2237","position":13,"is_corresponding":false},{"id":366400,"name":"Renée M. Tsolis","orcid":"0000-0001-9131-6657","position":14,"is_corresponding":false},{"id":530465,"name":"Kristen L. Lokken-Toyli","orcid":"0000-0002-2058-2015","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:58:26.927596Z","pmid":"38374245","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}