{"doi":"10.1038/s41556-018-0045-z","title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","abstract":"N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m<sup>6</sup>A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m<sup>6</sup>A)C sequence. In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m<sup>6</sup>A-dependent manner under normal and stress conditions and therefore affect gene expression output. Moreover, the K homology domains of IGF2BPs are required for their recognition of m<sup>6</sup>A and are critical for their oncogenic functions. Thus, our work reveals a different facet of the m<sup>6</sup>A-reading process that promotes mRNA stability and translation, and highlights the functional importance of IGF2BPs as m<sup>6</sup>A readers in post-transcriptional gene regulation and cancer biology.","journal":"Nature Cell Biology","year":2018,"id":10618,"datarank":11.301291316267923,"base_score":8.031710375322042,"endowment":8.031710375322042,"self_citation_contribution":1.2047565562983065,"citation_network_contribution":10.096534759969616,"self_endowment_contribution":1.2047565562983065,"citer_contribution":10.096534759969616,"corpus_percentile":81.9,"corpus_rank":2492,"citation_count":3076,"citer_count":159,"citers_with_citation_signal":159,"citers_with_endowment":159,"datacite_reuse_total":0,"is_dataset":false,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2018-02-23","authors":[{"id":87789,"name":"Hengyou Weng","orcid":"0000-0001-6474-2861","position":1,"is_corresponding":false},{"id":87790,"name":"Wenju Sun","orcid":"0000-0001-6976-4664","position":2,"is_corresponding":false},{"id":87791,"name":"Xi Qin","orcid":"0000-0002-1154-5634","position":3,"is_corresponding":false},{"id":87792,"name":"Hailing Shi","orcid":"0000-0001-7355-378X","position":4,"is_corresponding":false},{"id":87793,"name":"Huizhe Wu","orcid":"0000-0001-7964-1342","position":5,"is_corresponding":false},{"id":87794,"name":"Boxuan Simen Zhao","orcid":null,"position":6,"is_corresponding":false},{"id":87795,"name":"Ana Mesquita","orcid":null,"position":7,"is_corresponding":false},{"id":4799,"name":"Chang Liu","orcid":"0000-0001-9398-3701","position":8,"is_corresponding":false},{"id":87796,"name":"Celvie L. 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