{"doi":"10.1038/s41551-024-01183-w","title":"Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation","abstract":null,"journal":"Nature Biomedical Engineering","year":2024,"id":613976,"datarank":0.6456097639806255,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":0.0,"self_endowment_contribution":0.6456097639806255,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":725900,"name":"Matthew I. Bury","orcid":"0000-0001-7128-2162","position":1,"is_corresponding":false},{"id":1301880,"name":"Larry Wang","orcid":"0009-0005-6961-7169","position":2,"is_corresponding":false},{"id":1211318,"name":"Joanna L. Ciatti","orcid":"0000-0001-5393-522X","position":3,"is_corresponding":false},{"id":1043094,"name":"Raudel Avila","orcid":"0009-0005-0092-5307","position":4,"is_corresponding":false},{"id":236107,"name":"Yonggang Huang","orcid":"0000-0002-0483-8359","position":5,"is_corresponding":false},{"id":725902,"name":"Arun K. Sharma","orcid":"0000-0002-4504-3472","position":6,"is_corresponding":false},{"id":236111,"name":"John A. Rogers","orcid":"0000-0002-2980-3961","position":7,"is_corresponding":false},{"id":872886,"name":"Surabhi R. Madhvapathy","orcid":"0000-0001-9984-9482","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation","abstract":"Diagnosing and monitoring inflammatory bowel diseases, such as Crohn's disease, involves the use of endoscopic imaging, biopsies and serology. These infrequent tests cannot, however, identify sudden onsets and severe flare-ups to facilitate early intervention. Hence, about 70% of patients with Crohn's disease require surgical intestinal resections in their lifetime. Here we report wireless, miniaturized and implantable temperature sensors for the real-time chronic monitoring of disease progression, which we tested for nearly 4 months in a mouse model of Crohn's-disease-like ileitis. Local measurements of intestinal temperature via intraperitoneally implanted sensors held in place against abdominal muscular tissue via two sutures showed the development of ultradian rhythms at approximately 5 weeks before the visual emergence of inflammatory skip lesions. The ultradian rhythms showed correlations with variations in the concentrations of stress hormones and inflammatory cytokines in blood. Decreasing average temperatures over the span of approximately 23 weeks were accompanied by an increasing percentage of inflammatory species in ileal lesions. These miniaturized temperature sensors may aid the early treatment of inflammatory bowel diseases upon the detection of episodic flare-ups.","is_dataset_classified":null,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38499643","pmcid":null,"openalex_id":"https://openalex.org/W4392919069","authors":[],"funders":[{"funder_name":"National Science Foundation","grant_id":"NSF DGE-1842165","title":null},{"funder_name":"National Science Foundation","grant_id":"1842165","title":"Graduate Research Fellowship Program (GRFP)"},{"funder_name":"National Science Foundation","grant_id":"2234667","title":"Graduate Research Fellowship Program (GRFP)"},{"funder_name":"National Science Foundation","grant_id":"1720139","title":"MRSEC: Center for Multifunctional Materials"}],"total_grants":4,"fwci":28.4063,"citation_percentile":0.99795577,"influential_citations":0,"citation_trend":[{"year":2024,"count":10},{"year":2025,"count":45},{"year":2026,"count":18}],"oa_status":"closed","license":"Springer Nature TDM","oa_locations":[{"url":"https://www.nature.com/articles/s41551-024-01183-w.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41551-024-01183-w","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41551-024-01183-w","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38499643","host_type":"repository"}],"fields_of_study":["Inflammatory Bowel Disease","Systemic Lupus Erythematosus Research","Whipple's Disease and Interleukins"],"mesh_terms":["Animals","Body Temperature","Chronic Disease","Crohn Disease","Disease Models, Animal","Female","Inflammation","Intestines","Mice, Inbred C57BL","Miniaturization","Monitoring, Physiologic","Temperature","Cytokines","Prostheses and Implants","Mice","Wireless Technology"],"keywords":["Ileitis","Inflammatory bowel disease","Medicine","Crohn's disease","Inflammation","Short bowel syndrome","Disease","Internal medicine","Gastroenterology","Pathology","Parenteral nutrition","Miniaturization","Temperature","Prostheses and Implants","Body Temperature","Mice, Inbred C57BL","Intestines","Mice","Disease Models, Animal","Crohn Disease","Chronic Disease","Animals","Cytokines","Female","Wireless Technology","Monitoring, Physiologic"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T09:59:53.512937Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}