{"doi":"10.1038/s41541-025-01200-2","title":"Humoral immunity is sufficient to protect mice against Rift Valley fever encephalitis following percutaneous exposure","abstract":"In humans, Rift Valley fever virus (RVFV) infection typically presents as a self-limiting febrile illness but can cause severe complications. Neurological disease manifestations are particularly concerning as they are associated with increased mortality and long-term morbidity. This study demonstrated that vaccination with live attenuated RVFV was effective in preventing central nervous system (CNS) disease in the CC057/Unc mouse model of late-onset RVF encephalitis. Vaccine candidates (ΔNSs and ΔNSsΔNSm) were safe and immunogenic and elicited both RVFV-specific humoral and cellular immunity. Vaccinated mice survived percutaneous wild-type (WT) RVFV challenge and were protected from CNS disease. Naïve mice that received passive transfer of serum from vaccinated animals 2 days post-WT challenge were protected against late-onset encephalitis. These data demonstrate that humoral immunity is sufficient to protect against RVF encephalitis in CC057/Unc mice and suggest the potential of these vaccine candidates to prevent CNS disease in humans.","journal":"npj Vaccines","year":2025,"id":523791,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":474525,"name":"Dominique J. Barbeau","orcid":"0000-0001-6493-5022","position":1,"is_corresponding":false},{"id":1122293,"name":"Lingqing Xu","orcid":"0000-0002-6451-1673","position":2,"is_corresponding":false},{"id":235596,"name":"Brian H. Bird","orcid":"0000-0001-8170-8710","position":3,"is_corresponding":false},{"id":218428,"name":"Anita K. McElroy","orcid":"0000-0001-6764-7536","position":4,"is_corresponding":false},{"id":568522,"name":"Karina Mueller Brown","orcid":"0000-0001-5310-9876","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:50:07.396155Z","pmid":"40603312","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}