{"doi":"10.1038/s41541-024-01054-0","title":"Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae","abstract":"Neisseria gonorrhoeae is an on-going public health problem due in part to the lack of success with efforts to develop an efficacious vaccine to prevent this sexually transmitted infection. The gonococcal transferrin binding protein B (TbpB) is an attractive candidate vaccine antigen. However, it exhibits high levels of antigenic variability, posing a significant obstacle in evoking a broadly protective immune response. Here, we utilize phylogenetic information to rationally select TbpB variants for inclusion into a gonococcal vaccine and identify two TbpB variants that together elicit a highly cross-reactive antibody response against a diverse panel of TbpB variants and clinically relevant gonococcal strains. This formulation performed well in experimental proxies of real-world usage, including eliciting bactericidal activity against diverse gonococcal strains and decreasing the median duration of colonization after vaginal infection in female mice. These data support the use of a combination of TbpB variants for a broadly protective gonococcal vaccine.","journal":"npj Vaccines","year":2025,"id":517717,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":762828,"name":"Epshita A. Islam","orcid":null,"position":1,"is_corresponding":false},{"id":392965,"name":"David M. Curran","orcid":"0000-0003-2749-869X","position":2,"is_corresponding":false},{"id":1333865,"name":"Dixon Ng","orcid":"0000-0002-8615-1787","position":3,"is_corresponding":false},{"id":1384711,"name":"Natalie H. Au","orcid":"0000-0003-2420-6559","position":4,"is_corresponding":false},{"id":1334352,"name":"Elissa G. Currie","orcid":null,"position":5,"is_corresponding":false},{"id":225147,"name":"Joseph J. Zeppa","orcid":"0000-0003-1136-4793","position":6,"is_corresponding":false},{"id":1009966,"name":"Jessica Lam","orcid":"0009-0009-4272-7543","position":7,"is_corresponding":false},{"id":762352,"name":"Anthony B. Schryvers","orcid":"0000-0002-4029-3296","position":8,"is_corresponding":false},{"id":337216,"name":"Trevor F. Moraes","orcid":"0000-0001-9883-6145","position":9,"is_corresponding":false},{"id":646680,"name":"Scott D. Gray‐Owen","orcid":"0000-0002-1477-3616","position":10,"is_corresponding":false},{"id":762826,"name":"Jamie E. Fegan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T02:49:04.756302Z","pmid":"39814726","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}