{"doi":"10.1038/s41541-024-01036-2","title":"Establishing an immune correlate of protection for Nipah virus in nonhuman primates","abstract":"The limited but recurrent outbreaks of the zoonotic Nipah virus (NiV) infection in humans, its high fatality rate, and the potential virus transmission from human to human make NiV a concerning threat with pandemic potential. There are no licensed vaccines to prevent infection and disease. A recombinant Hendra virus soluble G glycoprotein vaccine (HeV-sG-V) candidate was recently tested in a Phase I clinical trial. Because NiV outbreaks are sporadic, and with a few cases, licensing will likely require an alternate regulatory licensing pathway. Therefore, determining a reliable vaccine correlate of protection (CoP) will be critical. We assessed the immune responses elicited by HeV-sG-V in African Green monkeys and its relationship with protection from a NiV challenge. Data revealed values of specific binding and neutralizing antibody titers that predicted survival and allowed us to establish a mechanistic CoP for NiV Bangladesh and Malaysia strains.","journal":"npj Vaccines","year":2024,"id":429097,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1231765,"name":"Dominique Promeneur","orcid":null,"position":1,"is_corresponding":false},{"id":242845,"name":"Krystle N. Agans","orcid":"0000-0002-7319-6935","position":2,"is_corresponding":false},{"id":1231766,"name":"Glorie G. Lazaro","orcid":null,"position":3,"is_corresponding":false},{"id":124945,"name":"Viktoriya Borisevich","orcid":null,"position":4,"is_corresponding":false},{"id":242846,"name":"Daniel J. Deer","orcid":"0009-0005-4744-8560","position":5,"is_corresponding":false},{"id":1231767,"name":"Amara Luckay","orcid":null,"position":6,"is_corresponding":false},{"id":304918,"name":"Michael Egan","orcid":"0000-0002-9709-1206","position":7,"is_corresponding":false},{"id":638436,"name":"Antony S. Dimitrov","orcid":"0000-0001-8356-6701","position":8,"is_corresponding":false},{"id":1231204,"name":"B. Small","orcid":"0000-0002-9577-7079","position":9,"is_corresponding":false},{"id":533697,"name":"Christopher C. Broder","orcid":"0000-0001-5382-0510","position":10,"is_corresponding":false},{"id":242853,"name":"Robert W. Cross","orcid":"0000-0001-7718-1522","position":11,"is_corresponding":false},{"id":1231205,"name":"Svetlana Hamm","orcid":"0000-0002-8593-0076","position":12,"is_corresponding":false},{"id":242852,"name":"Thomas W. Geisbert","orcid":"0000-0003-0858-1877","position":13,"is_corresponding":false},{"id":870345,"name":"Victor H. Leyva-Grado","orcid":"0000-0002-9211-6160","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:59:06.668462Z","pmid":"39702562","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}