{"doi":"10.1038/s41541-024-00859-3","title":"Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform","abstract":"Human cytomegalovirus (CMV) is the most common infectious cause of complications post-transplantation, while a CMV vaccine for transplant recipients has yet to be licensed. Triplex, a multiantigen Modified Vaccinia Ankara (MVA)-vectored CMV vaccine candidate based on the immunodominant antigens phosphoprotein 65 (pp65) and immediate-early 1 and 2 (IE1/2), is in an advanced stage of clinical development. However, its limited genetic and expression stability restricts its potential for large-scale production. Using a recently developed fully synthetic MVA (sMVA) platform, we developed a new generation Triplex vaccine candidate, T10-F10, with different sequence modifications for enhanced vaccine stability. T10-F10 demonstrated genetic and expression stability during extensive virus passaging. In addition, we show that T10-F10 confers comparable immunogenicity to the original Triplex vaccine to elicit antigen-specific T cell responses in HLA-transgenic mice. These results demonstrate improvements in translational vaccine properties of an sMVA-based CMV vaccine candidate designed as a therapeutic treatment for transplant recipients.","journal":"npj Vaccines","year":2024,"id":459362,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":280345,"name":"Yoonsuh Park","orcid":null,"position":1,"is_corresponding":false},{"id":280344,"name":"Joy Martinez","orcid":null,"position":2,"is_corresponding":false},{"id":280346,"name":"Angelina Iniguez","orcid":null,"position":3,"is_corresponding":false},{"id":276476,"name":"Mindy Kha","orcid":null,"position":4,"is_corresponding":false},{"id":548620,"name":"Tae Hyun Kim","orcid":"0000-0001-8413-3385","position":5,"is_corresponding":false},{"id":815226,"name":"Leonard Medrano","orcid":"0000-0002-0782-5473","position":6,"is_corresponding":false},{"id":279373,"name":"Vu H. Nguyen","orcid":"0000-0003-3974-7040","position":7,"is_corresponding":false},{"id":280347,"name":"Teodora Kaltcheva","orcid":null,"position":8,"is_corresponding":false},{"id":1088752,"name":"Shannon Dempsey","orcid":"0009-0000-2636-5831","position":9,"is_corresponding":false},{"id":274822,"name":"Flavia Chiuppesi","orcid":"0000-0002-2921-5377","position":10,"is_corresponding":false},{"id":274828,"name":"Felix Wussow","orcid":"0000-0001-7624-6734","position":11,"is_corresponding":false},{"id":274827,"name":"Don J. Diamond","orcid":"0000-0003-3579-7083","position":12,"is_corresponding":false},{"id":1064521,"name":"Marçal Yll","orcid":"0000-0002-7030-3360","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:03:55.280882Z","pmid":"38555379","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}