{"doi":"10.1038/s41523-025-00775-2","title":"Regular aspirin use, breast tumor characteristics and long-term breast cancer survival","abstract":"Epidemiologic data, supported by experiments, suggest aspirin may improve survival in breast cancer patients. However, recent trials reported a lack of protection, though the length of intervention was limited. Among 10,705 stages I-III breast cancer patients in the Nurses' Health Studies (NHS/NHSII), we examined the associations between post-diagnostic aspirin use and long-term breast cancer survival. During up to 34 years of follow-up, regular post-diagnostic aspirin use was associated with a 38% and 28% lower risk of breast cancer-specific and total mortality. Associations were more evident with longer duration of post-diagnostic aspirin use but attenuated with higher stage and older age at diagnosis. Pre-diagnostic long-term aspirin use was associated with the downregulation of tumor proliferation pathways in NHS/NHSII and the aspirin-gene-expression-signature predicted better survival in METABRIC. Our study highlighted the need for trials with longer duration and suggested that aspirin use before diagnosis may alter the tumor-microenvironment towards a less proliferative type.","journal":"npj Breast Cancer","year":2025,"id":532602,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":519542,"name":"Tengteng Wang","orcid":"0000-0001-9001-186X","position":1,"is_corresponding":false},{"id":337318,"name":"Michelle D. Holmes","orcid":"0000-0002-8664-2172","position":2,"is_corresponding":false},{"id":238429,"name":"Wendy Y. Chen","orcid":"0000-0002-6946-1206","position":3,"is_corresponding":false},{"id":612735,"name":"Kristen D. Brantley","orcid":"0000-0003-0084-4775","position":4,"is_corresponding":false},{"id":1223237,"name":"Phuong Anh Le","orcid":null,"position":5,"is_corresponding":false},{"id":363597,"name":"Yujing J. Heng","orcid":"0000-0002-8930-817X","position":6,"is_corresponding":false},{"id":693004,"name":"Pepper J. Schedin","orcid":null,"position":7,"is_corresponding":false},{"id":246330,"name":"Bernard Rosner","orcid":"0000-0001-6907-0056","position":8,"is_corresponding":false},{"id":541548,"name":"W. C. Willett","orcid":null,"position":9,"is_corresponding":false},{"id":55362,"name":"Meir J. Stampfer","orcid":"0000-0001-8865-935X","position":10,"is_corresponding":false},{"id":321496,"name":"Rulla M. Tamimi","orcid":"0000-0003-2306-8668","position":11,"is_corresponding":false},{"id":104571,"name":"A. Heather Eliassen","orcid":"0000-0002-3961-6609","position":12,"is_corresponding":false},{"id":1413729,"name":"Cheng Peng","orcid":"0000-0003-4573-9098","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T02:51:23.237536Z","pmid":"40595613","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}