{"doi":"10.1038/s41467-024-55648-2","title":"Differences in natriuretic peptide response in self-identified white and black individuals: a physiological clinical trial","abstract":"Abstract Black individuals have lower plasma natriuretic peptide (NP) concentrations than white individuals. However, race-based differences in the NP response to physiological perturbations are unknown. In this physiological trial (NCT#03070184), we measured the NP [mid-regional atrial NP (MR-proANP), N-terminal pro-B-type NP (NT-proBNP), and BNP] response to physiological perturbations among healthy, self-identified Black and white participants aged 18-40 years. The primary and secondary outcomes were the change in plasma NP concentrations at 6 weeks after metoprolol (initiated at 50 mg/day and doubled every 2 weeks) and standardized, aerobic exercise (70% of their maximal oxygen uptake on a salt-standardized background), respectively. Among 40 Black [median age: 27 (22, 32) years; 21 (52.5%) women] and 40 white [median age: 25 (20, 30) years; 19 (47.5%) women] participants, exercise increased MR-proANP (Black: 35%; white: 43%), NT-proBNP (Black: 11%; white: 23%), and BNP (Black: 59%; white: 61%) in both self-reported races. Exercise was associated with an increase in plasma MR-proANP (p interaction : 0.25) and BNP (p interaction : 0.87) concentrations which did not vary by self-reported race. However, the increase in plasma NT-proBNP concentrations were higher in white participants than in Black participants. (p interaction : 0.04) Similarly, metoprolol therapy increased MR-proANP (Black: 18%; white: 16%), NT-proBNP (Black: 95%; white: 99%), and BNP (Black: 45%; white: 74%) in both self-reported races. The metoprolol-associated increase in plasma MR-proANP (p interaction : 0.85), NT-proBNP (p interaction : 0.94), and BNP (p interaction : 0.21) concentrations were similar by self-reported race. In conclusion, the higher increase in plasma NT-proBNP concentrationsamong white patients after exercise suggests that exercise may induce significant physiological variations in NP levels. ClinicalTrials.gov ID: NCT03070184.","journal":"Nature Communications","year":2025,"id":543101,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9458,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03070184"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":51211,"name":"Mokshad Gaonkar","orcid":"0000-0003-0309-6813","position":1,"is_corresponding":false},{"id":374781,"name":"Nirav Patel","orcid":"0000-0003-1798-1880","position":2,"is_corresponding":false},{"id":51215,"name":"Nehal Vekariya","orcid":"0009-0002-3372-8375","position":3,"is_corresponding":false},{"id":1091175,"name":"Krishin Yerabolu","orcid":"0009-0006-5678-7385","position":4,"is_corresponding":false},{"id":1430604,"name":"Jasninder Singh Dhaliwal","orcid":"0009-0001-9099-9377","position":5,"is_corresponding":false},{"id":329408,"name":"Thomas W. Buford","orcid":"0000-0002-9541-4358","position":6,"is_corresponding":false},{"id":321518,"name":"Barbara A. Gower","orcid":"0000-0001-8461-4613","position":7,"is_corresponding":false},{"id":51220,"name":"Peng Li","orcid":"0000-0002-9026-9999","position":8,"is_corresponding":false},{"id":22019,"name":"Thomas J. Wang","orcid":"0000-0003-4063-6508","position":9,"is_corresponding":false},{"id":51221,"name":"Garima Arora","orcid":"0000-0001-6402-6910","position":10,"is_corresponding":false},{"id":51222,"name":"Pankaj Arora","orcid":"0000-0003-2420-3550","position":11,"is_corresponding":false},{"id":51209,"name":"Naman S. Shetty","orcid":"0000-0003-3600-126X","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:53:00.171379Z","pmid":"39948072","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}