{"doi":"10.1038/s41467-024-55544-9","title":"CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses","abstract":"Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). However, poor compliance reduces ART effectiveness and leads to immune compromise, viral mutations, and disease co-morbidities. Here we develop a drug formulation in which a lipid-based nanoparticle (LBNP) carrying rilpivirine (RPV) is decorated with the C-C chemokine receptor type 5 (CCR5) targeting peptide. This facilitates extended drug persistence within myeloid cells. Particle delivery to viral reservoirs is tracked by positron emission tomography. The CCR5-mediated LBNP cell uptake and retention reduce HIV-1 replication in human monocyte-derived macrophages and infected humanized mice (hu mice). Focused ultrasound with microbubbles mediated blood brain barrier (BBB) disruption allows the CCR5-targeted LBNP to penetrate the BBB and reach brain myeloid cells. These findings offer a role for CCR5-targeted therapeutics in antiretroviral delivery to optimize HIV suppression. Here the authors made lipid-based CCR5-receptor targeted nanoparticles to facilitate cell-based delivery of the antiretroviral drug rilpivirine, improving HIV-1 suppression in cell and tissue reservoirs. Focused ultrasound facilitates penetrance of the nanoparticles across the blood-brain barrier where they enter myeloid cells in humanized mice.","journal":"Nature Communications","year":2025,"id":518794,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":856195,"name":"Sudipta Panja","orcid":"0000-0001-5692-450X","position":1,"is_corresponding":false},{"id":958150,"name":"Lubaba A. Zaman","orcid":null,"position":2,"is_corresponding":false},{"id":629181,"name":"Pravin Yeapuri","orcid":null,"position":3,"is_corresponding":false},{"id":736551,"name":"Shaurav Bhattarai","orcid":"0000-0002-5687-0705","position":4,"is_corresponding":false},{"id":236489,"name":"Santhi Gorantla","orcid":"0000-0002-9064-1084","position":5,"is_corresponding":false},{"id":69435,"name":"Linda Chang","orcid":"0000-0002-1267-0699","position":6,"is_corresponding":false},{"id":451490,"name":"Alonso Heredia","orcid":"0000-0001-7468-8504","position":7,"is_corresponding":false},{"id":416236,"name":"Piotr Walczak","orcid":"0000-0002-3733-3322","position":8,"is_corresponding":false},{"id":868098,"name":"Brandon Hanson","orcid":null,"position":9,"is_corresponding":false},{"id":662229,"name":"Samuel M. Cohen","orcid":"0000-0002-5047-0962","position":10,"is_corresponding":false},{"id":109791,"name":"Bhavesh D. Kevadiya","orcid":"0000-0002-9119-7798","position":11,"is_corresponding":false},{"id":109790,"name":"Howard E. Gendelman","orcid":"0000-0002-7831-0370","position":12,"is_corresponding":false},{"id":109787,"name":"Milankumar Patel","orcid":"0000-0002-6412-6337","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:49:14.184995Z","pmid":"39779664","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}