{"doi":"10.1038/s41467-024-53715-2","title":"The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo","abstract":"We report that the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for differential gene expression in cells produced by asymmetric cell divisions in C. elegans. We found that the C. elegans CMG component, PSF-2 GINS2, is necessary for transcriptional upregulation of the pro-apoptotic gene egl-1 BH3-only that occurs in cells programmed to die after they are produced through asymmetric cell divisions. We propose that CMG's histone chaperone activity causes epigenetic changes at the egl-1 locus during replication in mother cells, and that these changes are required for egl-1 upregulation in cells programmed to die. We find that PSF-2 is also required for the divergence of other cell fates during C. elegans development, suggesting that this function is not unique to egl-1 expression. Our work uncovers an unexpected role of CMG in cell fate decisions and an intrinsic mechanism for gene expression plasticity in the context of asymmetric cell division.","journal":"Nature Communications","year":2024,"id":445860,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1103130,"name":"Ryan Sherrard","orcid":"0000-0001-8778-7130","position":1,"is_corresponding":false},{"id":1262242,"name":"Aditya Sethi","orcid":"0000-0002-6863-7505","position":2,"is_corresponding":false},{"id":328029,"name":"Carla Lloret-Fernández","orcid":"0000-0002-5370-9318","position":3,"is_corresponding":false},{"id":1262668,"name":"Henning Schmidt","orcid":null,"position":4,"is_corresponding":false},{"id":232826,"name":"Eric J. Lambie","orcid":"0000-0002-7371-128X","position":5,"is_corresponding":false},{"id":328036,"name":"Richard J. Poole","orcid":"0000-0001-6414-2479","position":6,"is_corresponding":false},{"id":775876,"name":"Ralf Schnabel","orcid":"0000-0003-2976-041X","position":7,"is_corresponding":false},{"id":277597,"name":"Barbara Conradt","orcid":"0000-0002-3731-4308","position":8,"is_corresponding":false},{"id":998513,"name":"Nadin Memar","orcid":"0000-0002-0913-1328","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:46.243344Z","pmid":"39477966","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}