{"doi":"10.1038/s41467-024-49443-2","title":"Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective","abstract":"Abstract As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed highly efficacious, intranasal trivalent SARS-CoV-2 vaccine candidates (TVC) based on three components of the MMR vaccine: measles virus (MeV), mumps virus (MuV) Jeryl Lynn (JL1) strain, and MuV JL2 strain. Specifically, MeV, MuV-JL1, and MuV-JL2 vaccine strains, each expressing prefusion spike (preS-6P) from a different variant of concern (VoC), were combined to generate TVCs. Intranasal immunization of IFNAR1 −/− mice and female hamsters with TVCs generated high levels of S-specific serum IgG antibodies, broad neutralizing antibodies, and mucosal IgA antibodies as well as tissue-resident memory T cells in the lungs. The immunized female hamsters were protected from challenge with SARS-CoV-2 original WA1, B.1.617.2, and B.1.1.529 strains. The preexisting MeV and MuV immunity does not significantly interfere with the efficacy of TVC. Thus, the trivalent platform is a promising next-generation SARS-CoV-2 vaccine candidate.","journal":"Nature Communications","year":2024,"id":427822,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1090801,"name":"Michelle Chamblee","orcid":"0000-0002-9794-4504","position":1,"is_corresponding":false},{"id":554566,"name":"Jiayu Xu","orcid":"0009-0009-9050-5435","position":2,"is_corresponding":false},{"id":278005,"name":"Panke Qu","orcid":"0000-0002-0222-365X","position":3,"is_corresponding":false},{"id":1090798,"name":"Mohamed M. Shamseldin","orcid":"0000-0002-5324-1145","position":4,"is_corresponding":false},{"id":1090799,"name":"Sung J. Yoo","orcid":"0000-0002-0892-2718","position":5,"is_corresponding":false},{"id":1091166,"name":"Jack Misny","orcid":null,"position":6,"is_corresponding":false},{"id":1090800,"name":"Ilada Thongpan","orcid":"0000-0002-6656-3530","position":7,"is_corresponding":false},{"id":652407,"name":"Mahesh KC","orcid":null,"position":8,"is_corresponding":false},{"id":400832,"name":"Jesse M. Hall","orcid":null,"position":9,"is_corresponding":false},{"id":1140020,"name":"Yash Gupta","orcid":"0000-0003-3002-1315","position":10,"is_corresponding":false},{"id":278003,"name":"John P. Evans","orcid":"0000-0001-8644-5825","position":11,"is_corresponding":false},{"id":236189,"name":"Mijia Lu","orcid":"0000-0002-4438-980X","position":12,"is_corresponding":false},{"id":2361,"name":"Chengjin Ye","orcid":"0000-0002-1934-9494","position":13,"is_corresponding":false},{"id":1202878,"name":"Cheng Chih Hsu","orcid":"0000-0003-3813-4373","position":14,"is_corresponding":false},{"id":238850,"name":"Xueya Liang","orcid":null,"position":15,"is_corresponding":false},{"id":2423,"name":"Luis Martínez‐Sobrido","orcid":"0000-0001-7084-0804","position":16,"is_corresponding":false},{"id":241044,"name":"Jacob S. Yount","orcid":"0000-0002-6128-4575","position":17,"is_corresponding":false},{"id":315472,"name":"Prosper N. Boyaka","orcid":"0000-0001-6857-9088","position":18,"is_corresponding":false},{"id":278009,"name":"Shan‐Lu Liu","orcid":"0000-0003-1620-3817","position":19,"is_corresponding":false},{"id":497430,"name":"Purnima Dubey","orcid":"0000-0002-5454-8421","position":20,"is_corresponding":false},{"id":236197,"name":"Mark E. Peeples","orcid":"0000-0002-4582-317X","position":21,"is_corresponding":false},{"id":236198,"name":"Jiànróng Lǐ","orcid":"0000-0002-7130-1084","position":22,"is_corresponding":false},{"id":651168,"name":"Yuexiu Zhang","orcid":"0000-0002-3948-1425","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:52.576447Z","pmid":"38961063","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}