{"doi":"10.1038/s41467-024-48841-w","title":"Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight","abstract":"As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated \"spaceflight secretome profiles,\" which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins. While >93% of differentially abundant proteins (DAPs) in vesicles and metabolites recovered within six months, the majority (73%) of plasma DAPs were still perturbed post-flight. Moreover, these proteomic alterations correlated better with peripheral blood mononuclear cells than whole blood, suggesting that immune cells contribute more DAPs than erythrocytes. Finally, to discern possible mechanisms leading to brain-enriched protein detection and blood-brain barrier (BBB) disruption, we examined protein changes in dissected brains of spaceflight mice, which showed increases in PECAM-1, a marker of BBB integrity. These data highlight how even short-duration spaceflight can disrupt human and murine physiology and identify spaceflight biomarkers that can guide countermeasure development.","journal":"Nature Communications","year":2024,"id":419259,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9349,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1163545,"name":"JangKeun Kim","orcid":"0000-0002-8733-9925","position":1,"is_corresponding":false},{"id":1163544,"name":"Eliah Overbey","orcid":"0000-0002-2866-8294","position":2,"is_corresponding":false},{"id":1248,"name":"Richa Batra","orcid":"0000-0003-3708-0086","position":3,"is_corresponding":false},{"id":816121,"name":"Annalise Schweickart","orcid":"0000-0001-9691-3741","position":4,"is_corresponding":false},{"id":1167079,"name":"Laura Pătraș","orcid":"0000-0002-6981-3881","position":5,"is_corresponding":false},{"id":106399,"name":"Serena Lucotti","orcid":"0000-0003-1318-4761","position":6,"is_corresponding":false},{"id":550379,"name":"Krista Ryon","orcid":"0000-0001-9440-2729","position":7,"is_corresponding":false},{"id":1167078,"name":"Deena Najjar","orcid":"0009-0009-7950-2866","position":8,"is_corresponding":false},{"id":227777,"name":"Cem Meydan","orcid":"0000-0002-0663-6216","position":9,"is_corresponding":false},{"id":1113040,"name":"Namita Damle","orcid":null,"position":10,"is_corresponding":false},{"id":237408,"name":"Christopher R. 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