{"doi":"10.1038/s41467-024-48746-8","title":"Differential cortical layer engagement during seizure initiation and spread in humans","abstract":"Despite decades of research, we still do not understand how spontaneous human seizures start and spread - especially at the level of neuronal microcircuits. In this study, we used laminar arrays of micro-electrodes to simultaneously record the local field potentials and multi-unit neural activities across the six layers of the neocortex during focal seizures in humans. We found that, within the ictal onset zone, the discharges generated during a seizure consisted of current sinks and sources only within the infra-granular and granular layers. Outside of the seizure onset zone, ictal discharges reflected current flow in the supra-granular layers. Interestingly, these patterns of current flow evolved during the course of the seizure - especially outside the seizure onset zone where superficial sinks and sources extended into the deeper layers. Based on these observations, a framework describing cortical-cortical dynamics of seizures is proposed with implications for seizure localization, surgical targeting, and neuromodulation techniques to block the generation and propagation of seizures.","journal":"Nature Communications","year":2024,"id":426045,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9454,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":833752,"name":"Liankun Ren","orcid":"0000-0001-5147-3068","position":1,"is_corresponding":false},{"id":678590,"name":"Mila Halgren","orcid":"0000-0003-2871-741X","position":2,"is_corresponding":false},{"id":407114,"name":"Angelique C. Paulk","orcid":"0000-0002-4413-3417","position":3,"is_corresponding":false},{"id":478595,"name":"Pariya Salami","orcid":"0000-0001-6260-8634","position":4,"is_corresponding":false},{"id":360771,"name":"István Ulbert","orcid":"0000-0001-9941-9159","position":5,"is_corresponding":false},{"id":360772,"name":"Dániel Fabó","orcid":"0000-0001-5141-5351","position":6,"is_corresponding":false},{"id":352585,"name":"Jean-Rémi King","orcid":"0000-0002-2121-170X","position":7,"is_corresponding":false},{"id":1224849,"name":"K. M. Sjoberg","orcid":"0000-0001-7348-9220","position":8,"is_corresponding":false},{"id":333806,"name":"Emad N. Eskandar","orcid":"0000-0003-4743-2938","position":9,"is_corresponding":false},{"id":448378,"name":"Joseph R. Madsen","orcid":null,"position":10,"is_corresponding":false},{"id":404982,"name":"Eric Halgren","orcid":"0000-0001-5926-6872","position":11,"is_corresponding":false},{"id":227177,"name":"Sydney S. Cash","orcid":"0000-0002-4557-6391","position":12,"is_corresponding":false},{"id":1224848,"name":"Pierre Bourdillon","orcid":"0000-0002-8441-1311","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:37.924718Z","pmid":"38886376","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}