{"doi":"10.1038/s41467-024-46396-4","title":"Dynamic enhancer landscapes in human craniofacial development","abstract":"The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development. However, a lack of accurate maps of the genomic locations and cell type-resolved activities of craniofacial enhancers prevents their systematic exploration in human genetics studies. Here, we combine histone modification, chromatin accessibility, and gene expression profiling of human craniofacial development with single-cell analyses of the developing mouse face to define the regulatory landscape of facial development at tissue- and single cell-resolution. We provide temporal activity profiles for 14,000 human developmental craniofacial enhancers. We find that 56% of human craniofacial enhancers share chromatin accessibility in the mouse and we provide cell population- and embryonic stage-resolved predictions of their in vivo activity. Taken together, our data provide an expansive resource for genetic and developmental studies of human craniofacial development.","journal":"Nature Communications","year":2024,"id":422162,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":398243,"name":"Kitt Paraiso","orcid":"0000-0002-6489-810X","position":1,"is_corresponding":false},{"id":851625,"name":"Maria Luisa Amaral","orcid":"0000-0001-6346-9381","position":2,"is_corresponding":false},{"id":869652,"name":"Michael Kosicki","orcid":"0000-0001-7173-8852","position":3,"is_corresponding":false},{"id":1146763,"name":"Laura Cook","orcid":"0000-0002-4459-2592","position":4,"is_corresponding":false},{"id":457316,"name":"Fabrice Darbellay","orcid":"0000-0001-6942-3325","position":5,"is_corresponding":false},{"id":445227,"name":"Cailyn H. 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