{"doi":"10.1038/s41467-024-45260-9","title":"Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk","abstract":"In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age. Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.5 years in median biological age, independent of weight loss. Nearly identical findings resulted from a second clinical study (NCT04150159). Together these results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.","journal":"Nature Communications","year":2024,"id":417937,"datarank":1.1560332923419852,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":0.5418816080086701,"self_endowment_contribution":0.6141516843333151,"citer_contribution":0.5418816080086701,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":57,"citers_with_citation_signal":28,"citers_with_endowment":28,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04150159"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":218505,"name":"Morgan E. Levine","orcid":"0000-0001-9890-9324","position":1,"is_corresponding":false},{"id":231505,"name":"Min Wei","orcid":"0000-0002-2649-9271","position":2,"is_corresponding":false},{"id":1205203,"name":"Mahshid Shelehchi","orcid":null,"position":3,"is_corresponding":false},{"id":458325,"name":"Todd E. Morgan","orcid":"0000-0002-9874-5080","position":4,"is_corresponding":false},{"id":280605,"name":"Krishna S. Nayak","orcid":"0000-0001-5735-3550","position":5,"is_corresponding":false},{"id":441989,"name":"Tanya B. Dorff","orcid":"0000-0001-5990-298X","position":6,"is_corresponding":false},{"id":1204583,"name":"Kurt Hong","orcid":"0000-0002-7716-683X","position":7,"is_corresponding":false},{"id":256213,"name":"Eileen M. Crimmins","orcid":"0000-0001-5459-5239","position":8,"is_corresponding":false},{"id":278840,"name":"Pinchas Cohen","orcid":"0000-0002-0035-8366","position":9,"is_corresponding":false},{"id":231526,"name":"Valter D. Longo","orcid":"0000-0002-0946-7534","position":10,"is_corresponding":false},{"id":231506,"name":"Sebastian Brandhorst","orcid":"0000-0003-4131-0876","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T01:56:56.807779Z","pmid":"38378685","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}