{"doi":"10.1038/s41467-024-44778-2","title":"Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity","abstract":"Abstract The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma cells eliminates clock function and diminishes hypoxic gene expression and tumorigenesis, which could be rescued by ectopic expression of HIF1α in YUMM2.1 cells. By contrast, over-expressed wild-type or a transcriptionally inactive mutant Bmal1 non-canonically sequester myosin heavy chain 9 (Myh9) to increase MRTF-SRF activity and AP-1 transcriptional signature, and shift YUMM2.1 cells from a Sox10 high to a Sox9 high immune resistant, mesenchymal cell state that is found in human melanomas. Our work describes a link between Bmal1, Myh9, mouse melanoma cell plasticity, and tumor immunity. This connection may underlie cancer therapeutic resistance and underpin the link between the circadian clock, MRTF-SRF and the cytoskeleton.","journal":"Nature Communications","year":2024,"id":429943,"datarank":0.672168892815407,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.20851252481165955,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.20851252481165955,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":19,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE202289"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1232598,"name":"Shishir M. Pant","orcid":"0000-0002-2686-7898","position":1,"is_corresponding":false},{"id":70383,"name":"Cecily C. Ritch","orcid":"0000-0001-7651-0419","position":2,"is_corresponding":false},{"id":258003,"name":"Hsin‐Yao Tang","orcid":"0000-0003-1838-018X","position":3,"is_corresponding":false},{"id":1232957,"name":"Hongguang Shao","orcid":null,"position":4,"is_corresponding":false},{"id":500647,"name":"Harsh Dweep","orcid":"0000-0003-4452-7042","position":5,"is_corresponding":false},{"id":283375,"name":"Yao-Yu Gong","orcid":null,"position":6,"is_corresponding":false},{"id":649494,"name":"Rebekah Brooks","orcid":"0000-0002-9795-5748","position":7,"is_corresponding":false},{"id":604743,"name":"Patricia Brafford","orcid":"0000-0002-4836-7421","position":8,"is_corresponding":false},{"id":810050,"name":"Adam J. Wolpaw","orcid":"0000-0002-1373-7648","position":9,"is_corresponding":false},{"id":628386,"name":"Yool Lee","orcid":"0000-0003-0498-3342","position":10,"is_corresponding":false},{"id":103978,"name":"Ashani T. Weeraratna","orcid":"0000-0003-0448-6952","position":11,"is_corresponding":false},{"id":259293,"name":"Amita Sehgal","orcid":"0000-0001-7354-9641","position":12,"is_corresponding":false},{"id":35706,"name":"Meenhard Herlyn","orcid":"0000-0003-0839-0739","position":13,"is_corresponding":false},{"id":245076,"name":"Andrew V. Kossenkov","orcid":"0000-0002-1536-0418","position":14,"is_corresponding":false},{"id":258005,"name":"David W. Speicher","orcid":"0000-0003-1311-4261","position":15,"is_corresponding":false},{"id":24147,"name":"Peter K. Sorger","orcid":"0000-0002-3364-1838","position":16,"is_corresponding":false},{"id":70392,"name":"Sandro Santagata","orcid":"0000-0002-7528-9668","position":17,"is_corresponding":false},{"id":7940,"name":"Chi V. Dang","orcid":"0000-0002-4031-2522","position":18,"is_corresponding":false},{"id":1232597,"name":"Xue Zhang","orcid":"0000-0001-9339-7040","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-19T01:59:11.328802Z","pmid":"38245503","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}