{"doi":"10.1038/s41467-019-12901-3","title":"Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist","abstract":"Interleukin-2 (IL-2) is a component of most protocols of adoptive cell transfer (ACT) therapy for cancer, but is limited by short exposure and high toxicities. NKTR-214 is a kinetically-engineered IL-2 receptor βγ (IL-2Rβγ)-biased agonist consisting of IL-2 conjugated to multiple releasable polyethylene glycol chains resulting in sustained signaling through IL-2Rβγ. We report that ACT supported by NKTR-214 increases the proliferation, homing and persistence of anti-tumor T cells compared to ACT with IL-2, resulting in superior antitumor activity in a B16-F10 murine melanoma model. The use of NKTR-214 increases the number of polyfunctional T cells in murine spleens and tumors compared to IL-2, and enhances the polyfunctionality of T and NK cells in the peripheral blood of patients receiving NKTR-214 in a phase 1 trial. In conclusion, NKTR-214 may have the potential to improve the antitumor activity of ACT in humans through increased in vivo expansion and polyfunctionality of the adoptively transferred T cells.","journal":"Nature Communications","year":2020,"id":55197,"datarank":2.469896684988943,"base_score":4.574710978503383,"endowment":4.574710978503383,"self_citation_contribution":0.6862066467755076,"citation_network_contribution":1.7836900382134355,"self_endowment_contribution":0.6862066467755076,"citer_contribution":1.7836900382134355,"corpus_percentile":null,"corpus_rank":null,"citation_count":96,"citer_count":79,"citers_with_citation_signal":71,"citers_with_endowment":71,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9637,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":287068,"name":"Justin D. Saco","orcid":null,"position":1,"is_corresponding":false},{"id":285134,"name":"Felix B. Salazar","orcid":"0009-0004-9361-1528","position":2,"is_corresponding":false},{"id":230450,"name":"Jennifer Tsoi","orcid":"0000-0001-7269-5161","position":3,"is_corresponding":false},{"id":259515,"name":"Paige Krystofinski","orcid":"0000-0001-8613-0954","position":4,"is_corresponding":false},{"id":226367,"name":"Cristina Puig-Saus","orcid":"0000-0002-3014-3649","position":5,"is_corresponding":false},{"id":285135,"name":"Ruixue Zhang","orcid":"0000-0002-9418-8125","position":6,"is_corresponding":false},{"id":109714,"name":"Jing Zhou","orcid":"0000-0001-6190-8053","position":7,"is_corresponding":false},{"id":261314,"name":"Gardenia Cheung-Lau","orcid":null,"position":8,"is_corresponding":false},{"id":285136,"name":"Alejandro J. Garcia","orcid":"0000-0001-9087-6193","position":9,"is_corresponding":false},{"id":230449,"name":"Catherine S. Grasso","orcid":"0000-0001-8632-4126","position":10,"is_corresponding":false},{"id":285137,"name":"Richard Tavaré","orcid":"0000-0001-5150-5963","position":11,"is_corresponding":false},{"id":259518,"name":"Siwen Hu‐Lieskovan","orcid":"0000-0001-5836-4710","position":12,"is_corresponding":false},{"id":109727,"name":"Sean Mackay","orcid":"0009-0006-4030-916X","position":13,"is_corresponding":false},{"id":285138,"name":"Jonathan Zalevsky","orcid":"0000-0003-2707-1709","position":14,"is_corresponding":false},{"id":72145,"name":"Chantale Bernatchez","orcid":"0000-0001-5926-3460","position":15,"is_corresponding":false},{"id":90456,"name":"Adi Diab","orcid":"0000-0002-0153-0244","position":16,"is_corresponding":false},{"id":285139,"name":"Anna M. Wu","orcid":"0000-0001-8487-823X","position":17,"is_corresponding":false},{"id":261316,"name":"Begoña Comı́n-Anduix","orcid":null,"position":18,"is_corresponding":false},{"id":285140,"name":"Deborah H. Charych","orcid":"0000-0002-1293-0366","position":19,"is_corresponding":false},{"id":58599,"name":"Antoni Ribas","orcid":"0000-0003-3669-8458","position":20,"is_corresponding":false},{"id":259513,"name":"Giulia Parisi","orcid":"0000-0002-2172-3078","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:04:59.506324Z","pmid":"32005809","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}