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Finally, we identify specific genes where modification of uORFs likely represents an important disease mechanism, and report a novel uORF frameshift variant upstream of NF2 in neurofibromatosis. Our results highlight uORF-perturbing variants as an under-recognised functional class that contribute to penetrant human disease, and demonstrate the power of large-scale population sequencing data in studying non-coding variant classes.","journal":"Nature Communications","year":2020,"id":5255,"datarank":5.225296958334084,"base_score":5.2574953720277815,"endowment":5.2574953720277815,"self_citation_contribution":0.7886243058041673,"citation_network_contribution":4.436672652529917,"self_endowment_contribution":0.7886243058041673,"citer_contribution":4.436672652529917,"corpus_percentile":null,"corpus_rank":null,"citation_count":191,"citer_count":146,"citers_with_citation_signal":116,"citers_with_endowment":116,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0441,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-05-27","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":47,"name":"Konrad J. 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