{"doi":"10.1038/s41435-024-00258-7","title":"CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study","abstract":null,"journal":"Genes &amp; Immunity","year":2024,"id":642981,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1672738,"name":"Zhihao Wen","orcid":null,"position":1,"is_corresponding":false},{"id":356731,"name":"Xin Zhang","orcid":"0000-0003-2000-858X","position":2,"is_corresponding":false},{"id":763037,"name":"Ying Yang","orcid":"0000-0003-2679-1755","position":3,"is_corresponding":false},{"id":356216,"name":"Yifei Li","orcid":"0000-0002-3096-4287","position":4,"is_corresponding":false},{"id":1672739,"name":"Ruoxi Liao","orcid":null,"position":5,"is_corresponding":false},{"id":1351575,"name":"Qin Zheng","orcid":"0000-0002-5174-5593","position":6,"is_corresponding":false},{"id":1469407,"name":"Yang Fu","orcid":"0000-0002-0378-2410","position":7,"is_corresponding":false},{"id":511400,"name":"Yu Liu","orcid":"0000-0002-4789-0288","position":8,"is_corresponding":false},{"id":545464,"name":"Hongyan Liao","orcid":"0000-0002-4741-5110","position":9,"is_corresponding":false},{"id":1672737,"name":"Xinran Xue","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study","abstract":"Controversial data have been reported on the prognostic value of C-X-C motif chemokine receptor 4 (CXCR4) in chronic lymphocytic leukemia (CLL). This prospective, single-center, observational study aimed to evaluate the role of CXCR4 in the pathophysiology of CLL and its prognostic role. A total of 158 patients of CLL were enrolled, and CXCR4 expression on CLL cells was detected by flow cytometry (FCM) at initial diagnosis. The patients were divided into 2 groups according to the CXCR4 mean fluorescence intensity (MFI) median. Also, four patient specimens from the CXCR4<sup>low</sup> and CXCR4<sup>high</sup> groups were selected for RNASeq analysis. The progression-free survival (PFS) of CLL patients in the CXCR4<sup>high</sup> group was significantly shorter than the CXCR4<sup>low</sup> group, with a median follow-up time of 27 months (log-rank P < 0.001). Moreover, CXCR4 overexpression (MFI > 3376) was an independent marker of poor PFS in CLL patients (P < 0.001). Analysis of RNASeq results revealed that CXCR4 plays an important role in the migration of CLL. Collectively, CXCR4 expression levels on leukemia cells can be detected rapidly by FCM. CXCR4 overexpression was significantly associated with poorer prognosis in CLL patients within a shorter follow-up time.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38366101","pmcid":null,"openalex_id":"https://openalex.org/W4391915334","authors":[],"funders":[],"total_grants":0,"fwci":2.2515,"citation_percentile":0.87573578,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://www.nature.com/articles/s41435-024-00258-7.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41435-024-00258-7","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41435-024-00258-7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38366101","host_type":"repository"}],"fields_of_study":["Chronic Lymphocytic Leukemia Research","Immunodeficiency and Autoimmune Disorders","Lymphoma Diagnosis and Treatment"],"mesh_terms":["Humans","Prognosis","Prospective Studies","Signal Transduction","Leukemia, Lymphocytic, Chronic, B-Cell","Receptors, CXCR4"],"keywords":["CXCR4","Chronic lymphocytic leukemia","Internal medicine","Biology","Oncology","Leukemia","Chemokine receptor","Single Center","Flow cytometry","Chemokine","Immunology","Medicine","Inflammation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T11:21:10.230754Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}