{"doi":"10.1038/s41392-024-01925-x","title":"Adhesion G protein-coupled receptor latrophilin 1 (ADGRL1): a novel regulator of glucose and energy homeostasis","abstract":"Recently, I read with interest the research article entitled ‘ Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity ’ 1 published in Signal Transduction and Targeted Therapy . This report confirms and extends our findings that ADGRL1 (aka latrophilin 1) regulates energy balance and glucose homeostasis. 2 Using affinity chromatography coupled with proteomics and electrophysiology, we showed that ADGRL1 is likely a glucose receptor in the hypothalamus. Our findings demonstrated that lack of ADGRL1 in the hypothalamus or whole-body causes obesity and features of type 2 diabetes in mice. It is refreshing to see Dietzsch et al. 1 reached the same conclusion.","journal":"Signal Transduction and Targeted Therapy","year":2024,"id":468715,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336224,"name":"Kavaljit H. Chhabra","orcid":"0000-0001-6378-3645","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-19T02:05:23.500722Z","pmid":"39080020","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}