{"doi":"10.1038/s41390-024-03371-5","title":"Sleep as a driver of pre- and postnatal brain development","abstract":"<jats:sec>\n                <jats:title>Abstract</jats:title>\n                <jats:p>In 1966, Howard Roffwarg proposed the ontogenic sleep hypothesis, relating neural plasticity and development to rapid eye movement (REM) sleep, a hypothesis that current fetal and neonatal sleep research is still exploring. Recently, technological advances have enabled researchers to automatically quantify neonatal sleep architecture, which has caused a resurgence of research in this field as attempts are made to further elucidate the important role of sleep in pre- and postnatal brain development. This article will review our current understanding of the role of sleep as a driver of brain development and identify possible areas for future research.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Impact</jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>The evidence to date suggests that Roffwarg’s ontogenesis hypothesis of sleep and brain development is correct.</jats:p>\n                  </jats:list-item>\n                  <jats:list-item>\n                    <jats:p>A better understanding of the relationship between sleep and the development of functional connectivity is needed.</jats:p>\n                  </jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Reliable, non-invasive tools to assess sleep in the NICU and at home need to be tested in a real-world environment and the best way to promote healthy sleep needs to be understood before clinical trials promoting and optimizing sleep quality in neonates could be undertaken.</jats:p>\n                  </jats:list-item>\n                </jats:list></jats:p>\n              </jats:sec>","journal":"Pediatric Research","year":2024,"id":663906,"datarank":0.6413120699075734,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.18463370424905987,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.18463370424905987,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":19,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":197573,"name":"Jeroen Dudink","orcid":"0000-0003-0446-3646","position":1,"is_corresponding":false},{"id":1733478,"name":"Topun Austin","orcid":"0000-0002-8428-8624","position":2,"is_corresponding":false},{"id":197572,"name":"Eline R. de Groot","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sleep as a driver of pre- and postnatal brain development","abstract":"<jats:sec>\n                <jats:title>Abstract</jats:title>\n                <jats:p>In 1966, Howard Roffwarg proposed the ontogenic sleep hypothesis, relating neural plasticity and development to rapid eye movement (REM) sleep, a hypothesis that current fetal and neonatal sleep research is still exploring. Recently, technological advances have enabled researchers to automatically quantify neonatal sleep architecture, which has caused a resurgence of research in this field as attempts are made to further elucidate the important role of sleep in pre- and postnatal brain development. This article will review our current understanding of the role of sleep as a driver of brain development and identify possible areas for future research.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Impact</jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>The evidence to date suggests that Roffwarg’s ontogenesis hypothesis of sleep and brain development is correct.</jats:p>\n                  </jats:list-item>\n                  <jats:list-item>\n                    <jats:p>A better understanding of the relationship between sleep and the development of functional connectivity is needed.</jats:p>\n                  </jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Reliable, non-invasive tools to assess sleep in the NICU and at home need to be tested in a real-world environment and the best way to promote healthy sleep needs to be understood before clinical trials promoting and optimizing sleep quality in neonates could be undertaken.</jats:p>\n                  </jats:list-item>\n                </jats:list></jats:p>\n              </jats:sec>","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38956219","pmcid":"PMC11624135","openalex_id":"https://openalex.org/W4400307505","authors":[],"funders":[],"total_grants":0,"fwci":4.6729,"citation_percentile":0.95851499,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":9},{"year":2026,"count":9}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/s41390-024-03371-5.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s41390-024-03371-5.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41390-024-03371-5","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41390-024-03371-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38956219","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11624135","host_type":"repository"},{"url":"https://www.repository.cam.ac.uk/handle/1810/377182","host_type":"repository"},{"url":"https://dspace.library.uu.nl/handle/1874/458139","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11624135/pdf/41390_2024_Article_3371.pdf","host_type":"repository"},{"url":"https://www.repository.cam.ac.uk/bitstreams/baa5ce99-9174-4b12-9632-756dd5059eaf/download","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11624135","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11624135?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Sleep and Wakefulness Research","Neonatal and fetal brain pathology","Neuroscience of respiration and sleep","Humans","Brain","Sleep","Infant, Newborn","Sleep, REM","Electroencephalography","Neuronal Plasticity","Animals"],"mesh_terms":["Animals","Brain","Electroencephalography","Humans","Infant, Newborn","Neuronal Plasticity","Sleep","Sleep, REM"],"keywords":["Sleep (system call)","Brain development","Neuroscience","Neuroplasticity","Psychology","Neuroscience of sleep","Eye movement","Non-rapid eye movement sleep","Computer science"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T00:07:56.608930Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}