{"doi":"10.1038/s41388-025-03412-1","title":"Cancer stem cells-derived exosomal TSPAN8 enhances non-stem cancer cells stemness and promotes malignant progression in PDAC","abstract":null,"journal":"Oncogene","year":2025,"id":672665,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":543914,"name":"Rujiao Liu","orcid":"0000-0002-6803-0594","position":1,"is_corresponding":false},{"id":1130790,"name":"Juan Jin","orcid":"0000-0003-3087-1555","position":2,"is_corresponding":false},{"id":1757506,"name":"Jingxuan Xv","orcid":null,"position":3,"is_corresponding":false},{"id":602101,"name":"Jiahao Wu","orcid":"0000-0002-4490-9262","position":4,"is_corresponding":false},{"id":1757507,"name":"Yijie Jin","orcid":null,"position":5,"is_corresponding":false},{"id":1757508,"name":"Yaya Zhang","orcid":null,"position":6,"is_corresponding":false},{"id":254719,"name":"Shan Chen","orcid":"0000-0002-2750-5063","position":7,"is_corresponding":false},{"id":605915,"name":"Bin Sun","orcid":"0000-0002-6959-1772","position":8,"is_corresponding":false},{"id":1757509,"name":"Mou-bin Lin","orcid":null,"position":9,"is_corresponding":false},{"id":1757510,"name":"Wumaier Reziya","orcid":null,"position":10,"is_corresponding":false},{"id":1626824,"name":"Junjian Li","orcid":"0000-0001-7970-4163","position":11,"is_corresponding":false},{"id":1398971,"name":"Haoyu Sun","orcid":"0000-0002-4741-998X","position":12,"is_corresponding":false},{"id":379412,"name":"Hongxia Wang","orcid":"0000-0001-5082-003X","position":13,"is_corresponding":false},{"id":728976,"name":"Bo Yu","orcid":"0000-0001-6039-4249","position":14,"is_corresponding":false},{"id":1363366,"name":"Guangjian Fan","orcid":"0000-0003-0684-1380","position":15,"is_corresponding":false},{"id":1169828,"name":"Wenting Liu","orcid":"0000-0002-7233-0741","position":16,"is_corresponding":false},{"id":402945,"name":"Xiaoyi Yang","orcid":"0000-0001-8501-6674","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cancer stem cells-derived exosomal TSPAN8 enhances non-stem cancer cells stemness and promotes malignant progression in PDAC","abstract":"Cancer stem cells (CSC) play a crucial role in pancreatic ductal adenocarcinoma (PDAC) progression and therapeutic resistance. However, the underlying mechanisms and potential targeted treatment strategies remain poorly understood. In this study, we employed single-cell RNA sequencing and exosomal profiling, identifying TSPAN8-enriched exosomes secreted by CSC, which are associated with poor survival rates in PDAC patients. They enhanced stemness in the surrounding non-stem cancer cells (NSCC) by activating the Sonic Hedgehog (Hh) signalling pathway. This exosomal TSPAN8-Hh signalling axis significantly increases the clonogenic ability, invasiveness, and chemoresistance of PDAC cells. Furthermore, TSPAN8-enriched exosomes promoted a higher stem cell frequency, tumourigenicity, and tumour growth rate in vivo, confirming their critical roles in PDAC malignant progression. Our findings underscore the importance of TSPAN8-enriched exosomes for CSC-NSCC communication during PDAC progression.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40251391","pmcid":null,"openalex_id":"https://openalex.org/W4409574525","authors":[],"funders":[],"total_grants":0,"fwci":1.2652,"citation_percentile":0.77562667,"influential_citations":0,"citation_trend":[{"year":2025,"count":3}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://www.nature.com/articles/s41388-025-03412-1.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41388-025-03412-1","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41388-025-03412-1","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40251391","host_type":"repository"}],"fields_of_study":["Extracellular vesicles in disease","MicroRNA in disease regulation","Circular RNAs in diseases","Humans","Tetraspanins","Neoplastic Stem Cells","Exosomes","Carcinoma, Pancreatic Ductal","Pancreatic Neoplasms","Disease Progression","Animals","Mice","Cell Line, Tumor","Signal Transduction","Hedgehog Proteins","Gene Expression Regulation, Neoplastic"],"mesh_terms":["Animals","Humans","Pancreatic Neoplasms","Neoplastic Stem Cells","Signal Transduction","Gene Expression Regulation, Neoplastic","Disease Progression","Carcinoma, Pancreatic Ductal","Cell Line, Tumor","Mice","Hedgehog Proteins","Exosomes","Tetraspanins"],"keywords":["Biology","Cancer stem cell","Stem cell","Cancer research","Cancer","Carcinogenesis","Cancer cell","Microvesicles","Cell biology","microRNA","Gene","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T10:13:14.897969Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}