{"doi":"10.1038/s41380-020-0774-9","title":"Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders","abstract":"Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s d (left fusiform gyrus) = -0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions.","journal":"Molecular Psychiatry","year":2020,"id":51340,"datarank":3.3581584600101455,"base_score":5.075173815233827,"endowment":5.075173815233827,"self_citation_contribution":0.7612760722850741,"citation_network_contribution":2.5968823877250715,"self_endowment_contribution":0.7612760722850741,"citer_contribution":2.5968823877250715,"corpus_percentile":null,"corpus_rank":null,"citation_count":159,"citer_count":133,"citers_with_citation_signal":109,"citers_with_endowment":109,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236180,"name":"Anbupalam Thalamuthu","orcid":"0000-0002-7114-1260","position":1,"is_corresponding":false},{"id":107842,"name":"Yuri Milaneschi","orcid":"0000-0002-3697-6617","position":2,"is_corresponding":false},{"id":107808,"name":"Dominik Grotegerd","orcid":"0000-0001-8718-0128","position":3,"is_corresponding":false},{"id":255923,"name":"Claas Flint","orcid":"0000-0001-5164-8227","position":4,"is_corresponding":false},{"id":235042,"name":"Ramona Leenings","orcid":"0000-0002-9137-7510","position":5,"is_corresponding":false},{"id":18106,"name":"Janik Goltermann","orcid":"0000-0003-3087-1002","position":6,"is_corresponding":false},{"id":255924,"name":"Maike Richter","orcid":"0000-0003-4078-3954","position":7,"is_corresponding":false},{"id":235022,"name":"Tim Hahn","orcid":"0000-0001-6541-3795","position":8,"is_corresponding":false},{"id":255925,"name":"Georg Woditsch","orcid":"0009-0001-0317-4423","position":9,"is_corresponding":false},{"id":233912,"name":"Klaus Berger","orcid":"0000-0001-8966-3684","position":10,"is_corresponding":false},{"id":233911,"name":"Marco Hermesdorf","orcid":"0000-0003-3541-7212","position":11,"is_corresponding":false},{"id":217,"name":"Andrew M. 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