{"doi":"10.1038/s41375-022-01665-3","title":"Il-1r1 drives leukemogenesis induced by Tet2 loss","abstract":"Loss of the ten-eleven translocation methylcytosine dioxygenase 2 ( Tet2 ) gene, which is commonly mutated in hematological malignancies, dysregulates inflammatory pathways, including the interleukin-1 (IL-1) pathway [ 1 , 2 , 3 ]. Roles for IL-1 signaling have been reported in terminally differentiated hematopoietic cells and in non-cell autonomous contexts [ 3 , 4 ]. However, our group demonstrated that inhibition of inflammatory pathways can suppress clonal hematopoiesis (CH), indicating potential direct roles for hematopoietic stem and progenitor cells (HSPCs) in inflammation [ 5 ]. As TET2 mutations are often present in HSPCs and provide these cells with a competitive advantage, dysregulation of the IL-1 pathway in HSPCs may contribute to leukemogenesis and may catalyze the progression of preleukemic states to malignancy [ 6 ].","journal":"Leukemia","year":2022,"id":247847,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":886128,"name":"Ramesh Kumar","orcid":"0000-0002-7545-4619","position":1,"is_corresponding":false},{"id":423638,"name":"Santhosh Kumar Pasupuleti","orcid":"0000-0001-5770-7187","position":2,"is_corresponding":false},{"id":886572,"name":"Kaman So","orcid":null,"position":3,"is_corresponding":false},{"id":334696,"name":"Chi Zhang","orcid":"0000-0001-9553-0925","position":4,"is_corresponding":false},{"id":335029,"name":"Reuben Kapur","orcid":"0000-0003-2225-1700","position":5,"is_corresponding":false},{"id":417339,"name":"Sarah S. Burns","orcid":"0000-0002-6907-2366","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T00:23:57.824223Z","pmid":"35962058","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}