{"doi":"10.1038/s41370-021-00299-4","title":"Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study","abstract":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>Maternal exposure to fine particulate matter (PM<jats:sub>2.5</jats:sub>) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM<jats:sub>2.5</jats:sub> are more harmful for maternal and foetal health.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Objective</jats:title>\n                <jats:p>We focused on exposure over the first trimester (0–13 weeks of gestation), which includes the early placentation period, and investigated whether PM<jats:sub>2.5</jats:sub> and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth).</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton infants within 23 Tokyo wards (≈627 km<jats:sup>2</jats:sup>). Using daily filter sampling of PM<jats:sub>2.5</jats:sub> at one monitoring location, we analysed carbon and ion components, and assigned the first trimester average of the respective pollutant concentrations to each woman.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>The ORs of placenta-mediated pregnancy complications were 1.14 (95% CI = 1.08–1.22) per 0.51 μg/m<jats:sup>3</jats:sup> (interquartile range) increase of organic carbon and 1.11 (1.03–1.18) per 0.06 μg/m<jats:sup>3</jats:sup> increase of sodium. Organic carbon was also associated with four individual complications. There was no association between ozone and outcome.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Significance</jats:title>\n                <jats:p>There were specific components of PM<jats:sub>2.5</jats:sub> that have adverse effects on maternal and foetal health.</jats:p>\n              </jats:sec>","journal":"Journal of Exposure Science &amp; Environmental Epidemiology","year":2022,"id":641976,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1669471,"name":"Seiichi Morokuma","orcid":null,"position":1,"is_corresponding":false},{"id":958852,"name":"Shin Yamazaki","orcid":"0000-0002-6691-1531","position":2,"is_corresponding":false},{"id":1669472,"name":"Akinori Takami","orcid":null,"position":3,"is_corresponding":false},{"id":1669473,"name":"Seiji Sugata","orcid":null,"position":4,"is_corresponding":false},{"id":1669474,"name":"Ayako Yoshino","orcid":null,"position":5,"is_corresponding":false},{"id":1669475,"name":"Yuki Takeda","orcid":null,"position":6,"is_corresponding":false},{"id":1669477,"name":"Kazushige Nakahara","orcid":null,"position":7,"is_corresponding":false},{"id":228929,"name":"Shinji Saito","orcid":"0000-0003-4982-4820","position":8,"is_corresponding":false},{"id":1669479,"name":"Junya Hoshi","orcid":null,"position":9,"is_corresponding":false},{"id":1669480,"name":"Kiyoko Kato","orcid":null,"position":10,"is_corresponding":false},{"id":1669481,"name":"Hiroshi Nitta","orcid":null,"position":11,"is_corresponding":false},{"id":1669483,"name":"Yuji Nishiwaki","orcid":null,"position":12,"is_corresponding":false},{"id":1669469,"name":"Takehiro Michikawa","orcid":"0000-0002-2298-5133","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study","abstract":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>Maternal exposure to fine particulate matter (PM<jats:sub>2.5</jats:sub>) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM<jats:sub>2.5</jats:sub> are more harmful for maternal and foetal health.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Objective</jats:title>\n                <jats:p>We focused on exposure over the first trimester (0–13 weeks of gestation), which includes the early placentation period, and investigated whether PM<jats:sub>2.5</jats:sub> and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth).</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton infants within 23 Tokyo wards (≈627 km<jats:sup>2</jats:sup>). Using daily filter sampling of PM<jats:sub>2.5</jats:sub> at one monitoring location, we analysed carbon and ion components, and assigned the first trimester average of the respective pollutant concentrations to each woman.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>The ORs of placenta-mediated pregnancy complications were 1.14 (95% CI = 1.08–1.22) per 0.51 μg/m<jats:sup>3</jats:sup> (interquartile range) increase of organic carbon and 1.11 (1.03–1.18) per 0.06 μg/m<jats:sup>3</jats:sup> increase of sodium. Organic carbon was also associated with four individual complications. There was no association between ozone and outcome.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Significance</jats:title>\n                <jats:p>There were specific components of PM<jats:sub>2.5</jats:sub> that have adverse effects on maternal and foetal health.</jats:p>\n              </jats:sec>","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33603097","pmcid":"PMC8770113","openalex_id":"https://openalex.org/W3132431624","authors":[],"funders":[],"total_grants":0,"fwci":2.1999,"citation_percentile":0.86675307,"influential_citations":0,"citation_trend":[{"year":2021,"count":3},{"year":2022,"count":6},{"year":2023,"count":6},{"year":2024,"count":8},{"year":2025,"count":8},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/s41370-021-00299-4.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s41370-021-00299-4.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41370-021-00299-4","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41370-021-00299-4","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33603097","host_type":"repository"},{"url":"https://hdl.handle.net/2324/4476147","host_type":"repository"},{"url":"http://hdl.handle.net/2324/4476147","host_type":"repository"},{"url":"http://hdl.handle.net/2324/4793657","host_type":"repository"},{"url":"https://hdl.handle.net/2324/4793657","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8770113","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8770113","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8770113?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Air Quality and Health Impacts","Pregnancy and preeclampsia studies","Climate Change and Health Impacts","Air Pollutants","Air Pollution","Female","Humans","Maternal Exposure","Ozone","Particulate Matter","Placenta","Pregnancy","Pregnancy Complications","Tokyo"],"mesh_terms":["Air Pollutants","Air Pollution","Female","Humans","Ozone","Placenta","Pregnancy","Pregnancy Complications","Tokyo","Maternal Exposure","Particulate Matter"],"keywords":["Pregnancy","Obstetrics","Medicine","Interquartile range","Placental abruption","Placenta","Gestation","Preeclampsia","Fetus","Internal medicine","Biology","Chemical component","particulate matter","Placentation","Placenta-mediated Pregnancy Complications"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T21:06:11.940632Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}