{"doi":"10.1038/onc.2009.282","title":"Pro-proliferative FoxM1 is a target of p53-mediated repression","abstract":"The p53 tumor suppressor protein acts as a transcription factor to modulate cellular responses to a wide variety of stresses. In this study we show that p53 is required for the downregulation of FoxM1, an essential transcription factor that regulates many G2/M-specific genes and is overexpressed in a multitude of solid tumors. After DNA damage, p53 facilitates the repression of FoxM1 mRNA, which is accompanied by a decrease in FoxM1 protein levels. In cells with reduced p53 expression, FoxM1 is upregulated after DNA damage. Nutlin, a small-molecule activator of p53, suppresses FoxM1 levels in two cell lines in which DNA damage facilitates only mild repression. Mechanistically, p53-mediated inhibition of FoxM1 is partially p21 and retinoblastoma (Rb) family dependent, although in some cases p21-independent repression of FoxM1 was also observed. The importance of FoxM1 to cell fate was indicated by the observation that G2/M arrest follows FoxM1 ablation. Finally, our results indicate a potential contribution of p53-mediated repression of FoxM1 for maintenance of a stable G2 arrest.","journal":"Oncogene","year":2009,"id":6734,"datarank":7.864343575801682,"base_score":5.087596335232384,"endowment":5.087596335232384,"self_citation_contribution":0.7631394502848576,"citation_network_contribution":7.101204125516825,"self_endowment_contribution":0.7631394502848576,"citer_contribution":7.101204125516825,"corpus_percentile":null,"corpus_rank":null,"citation_count":161,"citer_count":158,"citers_with_citation_signal":142,"citers_with_endowment":142,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0453,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2009-09-14","algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":62208,"name":"C Prives","orcid":null,"position":1,"is_corresponding":false},{"id":62209,"name":"Anthony M. Barsotti","orcid":null,"position":2,"is_corresponding":false},{"id":62210,"name":"Carol Prives","orcid":"0000-0003-1846-5562","position":3,"is_corresponding":false},{"id":62207,"name":"A M Barsotti","orcid":null,"position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}