{"doi":"10.1038/nsmb1350","title":"Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions","abstract":null,"journal":"Nature Structural & Molecular Biology","year":2008,"id":676303,"datarank":5.190137841618442,"base_score":4.672828834461906,"endowment":4.672828834461906,"self_citation_contribution":0.7009243251692859,"citation_network_contribution":4.489213516449156,"self_endowment_contribution":0.7009243251692859,"citer_contribution":4.489213516449156,"corpus_percentile":null,"corpus_rank":null,"citation_count":106,"citer_count":106,"citers_with_citation_signal":92,"citers_with_endowment":92,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1709810,"name":"Heli Liu","orcid":null,"position":1,"is_corresponding":false},{"id":1767140,"name":"Ann H R Shim","orcid":null,"position":2,"is_corresponding":false},{"id":1767141,"name":"Pamela J Focia","orcid":null,"position":3,"is_corresponding":false},{"id":1376395,"name":"Xiaolin He","orcid":null,"position":4,"is_corresponding":false},{"id":175160,"name":"Xiaoyan Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions","abstract":"The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 A between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1beta (NX1beta) LNS (laminin, neurexin and sex hormone-binding globulin-like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca2+-mediated and solvent-supplemented interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1beta interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18084303","pmcid":"PMC2922956","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"1R01GM078055","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM078055","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2922956","host_type":"repository"},{"url":"http://www.nature.com/articles/nsmb1350.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nsmb1350","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Synapses","Humans","Calcium","Calcium-Binding Proteins","Cell Adhesion Molecules","Cell Adhesion Molecules, Neuronal","Neural Cell Adhesion Molecules","Membrane Proteins","Nerve Tissue Proteins","Autistic Disorder","Cell Adhesion","Alternative Splicing","Binding Sites","Protein Conformation","Models, Molecular"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T02:21:27.280778Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}