{"doi":"10.1038/nsmb1114","title":"Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme","abstract":null,"journal":"Nature Structural & Molecular Biology","year":2006,"id":633702,"datarank":0.8545640229758108,"base_score":5.697093486505405,"endowment":5.697093486505405,"self_citation_contribution":0.8545640229758108,"citation_network_contribution":0.0,"self_endowment_contribution":0.8545640229758108,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":297,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":146301,"name":"Xiangbin Zhang","orcid":null,"position":1,"is_corresponding":false},{"id":114513,"name":"Poonam Bheda","orcid":null,"position":2,"is_corresponding":false},{"id":1643148,"name":"Javier R Revollo","orcid":null,"position":3,"is_corresponding":false},{"id":115316,"name":"Shin-ichiro Imai","orcid":null,"position":4,"is_corresponding":false},{"id":48095,"name":"Cynthia Wolberger","orcid":"0000-0001-8578-2969","position":5,"is_corresponding":false},{"id":1054302,"name":"Tao Wang","orcid":"0000-0003-3322-7554","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme","abstract":"Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.","is_dataset_classified":null,"base_score":5.697093486505405,"endowment":5.697093486505405,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16783373","pmcid":null,"openalex_id":"https://openalex.org/W2024850262","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK056341","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"Y1-GM-1104","title":null},{"funder_name":"NCI NIH HHS","grant_id":"Y1-CO-1020","title":null},{"funder_name":"National Institutes of Health","grant_id":"Y1GM1104-15-0-1","title":"Technical Assistance to Support the Development of a GM/CA CAT Facility"}],"total_grants":4,"fwci":7.6976,"citation_percentile":0.98183231,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":16},{"year":2014,"count":19},{"year":2015,"count":16},{"year":2016,"count":12},{"year":2017,"count":16},{"year":2018,"count":15},{"year":2019,"count":14},{"year":2020,"count":20},{"year":2021,"count":19},{"year":2022,"count":13},{"year":2023,"count":12},{"year":2024,"count":20},{"year":2025,"count":19},{"year":2026,"count":1}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/nsmb1114.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nsmb1114","host_type":"publisher"},{"url":"https://doi.org/10.1038/nsmb1114","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16783373","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/nsmb1114","host_type":""}],"fields_of_study":["PARP inhibition in cancer therapy","Sirtuins and Resveratrol in Medicine","Calcium signaling and nucleotide metabolism","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Binding Sites","Crystallization","Cytokines","Mice","Models, Molecular","NAD","Nicotinamide Phosphoribosyltransferase","Protein Conformation"],"mesh_terms":["Animals","Binding Sites","Crystallization","Models, Molecular","NAD","Protein Conformation","Cytokines","Mice","Nicotinamide Phosphoribosyltransferase"],"keywords":["Nicotinamide phosphoribosyltransferase","Nicotinamide mononucleotide","NAD+ kinase","Enzyme","Chemistry","Phosphoribosyltransferase","Biochemistry","Nicotinamide","Nicotinamide adenine dinucleotide","Hypoxanthine-guanine phosphoribosyltransferase","Gene","Models, Molecular","Mice","Binding Sites","Protein Conformation","Animals","Cytokines","Crystallization","NAD"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12441665.v1","title":"Additional file 1 of Visfatin associated with major adverse cardiovascular events in patients with acute myocardial infarction","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.12441665","title":"Additional file 1 of Visfatin associated with major adverse cardiovascular events in patients with acute myocardial infarction","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26713807.v1","title":"Additional file 1 of Zebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26713807","title":"Additional file 1 of Zebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T12:31:29.081394Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}