{"doi":"10.1038/nrg751","title":"The art and design of genetic screens: Drosophila melanogaster","abstract":null,"journal":"Nature Reviews Genetics","year":2002,"id":650917,"datarank":0.9726952853452879,"base_score":6.484635235635252,"endowment":6.484635235635252,"self_citation_contribution":0.9726952853452879,"citation_network_contribution":0.0,"self_endowment_contribution":0.9726952853452879,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":654,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":398193,"name":"Daniel St Johnston","orcid":"0000-0001-5582-3301","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The art and design of genetic screens: Drosophila melanogaster","abstract":"The success of Drosophila melanogaster as a model organism is largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Traditional screens, such as the Nobel-prize-winning screen for embryonic-patterning mutants, can only identify the earliest phenotype of a mutation. This review describes the ingenious approaches that have been devised to circumvent this problem: modifier screens, for example, have been invaluable for elucidating signal-transduction pathways, whereas clonal screens now make it possible to screen for almost any phenotype in any cell at any stage of development.","is_dataset_classified":null,"base_score":6.484635235635252,"endowment":6.484635235635252,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11972155","pmcid":null,"openalex_id":"https://openalex.org/W2027125425","authors":[],"funders":[],"total_grants":0,"fwci":6.3501,"citation_percentile":0.97534696,"influential_citations":0,"citation_trend":[{"year":2012,"count":38},{"year":2013,"count":32},{"year":2014,"count":39},{"year":2015,"count":41},{"year":2016,"count":32},{"year":2017,"count":29},{"year":2018,"count":37},{"year":2019,"count":32},{"year":2020,"count":41},{"year":2021,"count":28},{"year":2022,"count":28},{"year":2023,"count":27},{"year":2024,"count":28},{"year":2025,"count":18},{"year":2026,"count":6}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/nrg751.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nrg751","host_type":"publisher"},{"url":"https://doi.org/10.1038/nrg751","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11972155","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Neurobiology and Insect Physiology Research","Genomics and Chromatin Dynamics","Animals","Crosses, Genetic","Drosophila melanogaster","Enhancer Elements, Genetic","Eye","Female","Gene Expression","Genes, Insect","Genes, Suppressor","Genetic Testing","Male","Mutagenesis","Phenotype"],"mesh_terms":["Animals","Crosses, Genetic","Drosophila melanogaster","Enhancer Elements, Genetic","Eye","Female","Genetic Testing","Male","Phenotype","Gene Expression","Genes, Suppressor","Mutagenesis","Genes, Insect"],"keywords":["Drosophila melanogaster","Genetic screen","Biology","Phenotype","Model organism","Drosophila (subgenus)","Mutant","Organism","Genetics","Forward genetics","Computational biology","Gene","Mutation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T06:20:55.657439Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}