{"doi":"10.1038/nrg3472","title":"Meta-analysis methods for genome-wide association studies and beyond","abstract":"Meta-analysis of genome-wide association studies (GWASs) has become a popular method for discovering genetic risk variants. Here, we overview both widely applied and newer statistical methods for GWAS meta-analysis, including issues of interpretation and assessment of sources of heterogeneity. We also discuss extensions of these meta-analysis methods to complex data. Where possible, we provide guidelines for researchers who are planning to use these methods. Furthermore, we address special issues that may arise for meta-analysis of sequencing data and rare variants. Finally, we discuss challenges and solutions surrounding the goals of making meta-analysis data publicly available and building powerful consortia.","journal":"Nature Reviews Genetics","year":2013,"id":1446,"datarank":0.9687507425017186,"base_score":6.45833828334479,"endowment":6.45833828334479,"self_citation_contribution":0.9687507425017186,"citation_network_contribution":0.0,"self_endowment_contribution":0.9687507425017186,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":637,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.045,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2013-05-09","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":1,"is_corresponding":false},{"id":2427,"name":"Evangelos Evangelou","orcid":"0000-0002-5488-2999","position":0,"is_corresponding":true}],"reference_count":117,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}