{"doi":"10.1038/nrg2987","title":"Regulation of X-chromosome inactivation by the X-inactivation centre","abstract":null,"journal":"Nature Reviews Genetics","year":2011,"id":595233,"datarank":0.8894383715084844,"base_score":5.929589143389895,"endowment":5.929589143389895,"self_citation_contribution":0.8894383715084844,"citation_network_contribution":0.0,"self_endowment_contribution":0.8894383715084844,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":375,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":243003,"name":"Elphège P. 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They have also revealed the existence of dosage-dependent activators that trigger XCI when more than one X chromosome is present, as well as possible mechanisms underlying the monoallelic regulation of this process. The recent discovery of the plasticity of the inactive state during early development, or during cloning, and induced pluripotency have also contributed to the X chromosome becoming a gold standard in reprogramming studies.","is_dataset_classified":null,"base_score":5.929589143389895,"endowment":5.929589143389895,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21587299","pmcid":null,"openalex_id":"https://openalex.org/W2081324839","authors":[],"funders":[{"funder_name":"NLM NIH HHS","grant_id":"U54 LM008748","title":null},{"funder_name":"European Commission","grant_id":"257082","title":"Epigenetics towards systems biology"}],"total_grants":2,"fwci":20.0005,"citation_percentile":0.99547917,"influential_citations":0,"citation_trend":[{"year":2012,"count":30},{"year":2013,"count":35},{"year":2014,"count":32},{"year":2015,"count":39},{"year":2016,"count":23},{"year":2017,"count":32},{"year":2018,"count":27},{"year":2019,"count":27},{"year":2020,"count":23},{"year":2021,"count":22},{"year":2022,"count":21},{"year":2023,"count":10},{"year":2024,"count":21},{"year":2025,"count":13},{"year":2026,"count":8}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/nrg2987.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nrg2987","host_type":"publisher"},{"url":"https://doi.org/10.1038/nrg2987","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21587299","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/nrg2987","host_type":""},{"url":"http://dx.doi.org/10.1038/nrg2987","host_type":""}],"fields_of_study":["Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Genetics and Neurodevelopmental Disorders","Animal Genetics and Reproduction","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Alleles","Animals","Cell Differentiation","Chromosomes","Dosage Compensation, Genetic","Gene Expression Regulation","Humans","Models, Genetic","RNA, Untranslated","Chromosomes, Human, X","X Chromosome Inactivation","Mice","Embryonic Stem Cells","RNA, Long Noncoding"],"keywords":["X-inactivation","Dosage compensation","Biology","Reprogramming","X chromosome","XIST","Genetics","Skewed X-inactivation","Chromosome","Cell biology","Gene dosage","Gene","Gene expression","Chromosomes, Human, X","RNA, Untranslated","Models, Genetic","Cell Differentiation","Chromosomes","Mice","Gene Expression Regulation","X Chromosome Inactivation","Dosage Compensation, Genetic","Animals","Humans","RNA, Long Noncoding","Alleles","Embryonic Stem Cells"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T16:56:01.338299Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}