{"doi":"10.1038/nrg2082","title":"Hybrid necrosis: autoimmunity as a potential gene-flow barrier in plant species","abstract":"Ecological factors, hybrid sterility and differences in ploidy levels are well known for contributing to gene-flow barriers in plants. Another common postzygotic incompatibility, hybrid necrosis, has received comparatively little attention in the evolutionary genetics literature. Hybrid necrosis is associated with a suite of phenotypic characteristics that are similar to those elicited in response to various environmental stresses, including pathogen attack. The genetic architecture is generally simple, and complies with the Bateson-Dobzhansky-Muller model for hybrid incompatibility between species. We survey the extensive literature on this topic and present the hypothesis that hybrid necrosis can result from autoimmunity, perhaps as a pleiotropic effect of evolution of genes that are involved in pathogen response.","journal":"Nature Reviews Genetics","year":2007,"id":11804,"datarank":0.9170523269748349,"base_score":6.113682179832232,"endowment":6.113682179832232,"self_citation_contribution":0.9170523269748349,"citation_network_contribution":0.0,"self_endowment_contribution":0.9170523269748349,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":451,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0468,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2007-04-03","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":6849,"name":"Detlef Weigel","orcid":"0000-0002-2114-7963","position":1,"is_corresponding":false},{"id":94841,"name":"Kirsten Bomblies","orcid":"0000-0002-2434-3863","position":0,"is_corresponding":true}],"reference_count":149,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}