{"doi":"10.1038/npp.2017.126","title":"Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling","abstract":null,"journal":"Neuropsychopharmacology","year":2018,"id":622408,"datarank":0.7574784010874307,"base_score":5.049856007249537,"endowment":5.049856007249537,"self_citation_contribution":0.7574784010874307,"citation_network_contribution":0.0,"self_endowment_contribution":0.7574784010874307,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":155,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1608156,"name":"J F Cheer","orcid":null,"position":1,"is_corresponding":false},{"id":1608154,"name":"J M Wenzel","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling","abstract":"The endocannabinoid system (eCB) is implicated in the mediation of both reward and reinforcement. This is evidenced by the ability of exogenous cannabinoid drugs to produce hedonia and maintain self-administration in both human and animal subjects. eCBs similarly facilitate behaviors motivated by reward through interaction with the mesolimbic dopamine (DA) and endogenous opioid systems. Indeed, eCB signaling in the ventral tegmental area stimulates activation of midbrain DA cells and promotes DA release in terminal regions such as the nucleus accumbens (NAc). DA transmission mediates several aspects of reinforced behavior, such as motivation, incentive salience, and cost-benefit calculations. However, much research suggests that endogenous opioid signaling underlies the hedonic aspects of reward. eCBs and their receptors functionally interact with opioid systems within the NAc to support reward, most likely through augmenting DA release. This review explores the interaction of these systems as it relates to reward and reinforcement and examines current literature regarding their role in food reward.","is_dataset_classified":null,"base_score":5.049856007249537,"endowment":5.049856007249537,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28653666","pmcid":"PMC5719091","openalex_id":"https://openalex.org/W2728347168","authors":[],"funders":[],"total_grants":0,"fwci":9.2971,"citation_percentile":0.9866671,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":10},{"year":2019,"count":12},{"year":2020,"count":23},{"year":2021,"count":23},{"year":2022,"count":20},{"year":2023,"count":16},{"year":2024,"count":11},{"year":2025,"count":28},{"year":2026,"count":8}],"oa_status":"bronze","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://www.nature.com/articles/npp2017126.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/npp2017126.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/npp2017126.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/npp2017126","host_type":"publisher"},{"url":"http://www.nature.com/doifinder/10.1038/npp.2017.126","host_type":"publisher"},{"url":"https://doi.org/10.1038/npp.2017.126","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28653666","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC5719091","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5719091","host_type":"repository"}],"fields_of_study":["Cannabis and Cannabinoid Research","Neurotransmitter Receptor Influence on Behavior","Neuroscience and Neuropharmacology Research"],"mesh_terms":["Animals","Brain","Dopamine","Humans","Reinforcement, Psychology","Opioid Peptides"],"keywords":["Ventral tegmental area","Nucleus accumbens","Incentive salience","Endocannabinoid system","Reward system","Neuroscience","Dopamine","Mesolimbic pathway","Endogenous opioid","Brain stimulation reward","Conditioned place preference","Opioid","Psychology","Reinforcement","Cannabinoid","Cannabinoid receptor","Addiction","Dopaminergic","Receptor","Medicine","Internal medicine","Antagonist"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T19:30:08.531052Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}