{"doi":"10.1038/npp.2014.172","title":"Neural Signatures of Autism Spectrum Disorders: Insights into Brain Network Dynamics","abstract":null,"journal":"Neuropsychopharmacology","year":2015,"id":611012,"datarank":0.750591945891819,"base_score":5.003946305945459,"endowment":5.003946305945459,"self_citation_contribution":0.750591945891819,"citation_network_contribution":0.0,"self_endowment_contribution":0.750591945891819,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":148,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1571185,"name":"Jeffrey D Rudie","orcid":null,"position":1,"is_corresponding":false},{"id":1571186,"name":"Shulamite A Green","orcid":null,"position":2,"is_corresponding":false},{"id":1518660,"name":"Susan Bookheimer","orcid":null,"position":3,"is_corresponding":false},{"id":285324,"name":"Mirella Dapretto","orcid":"0000-0003-2914-6858","position":4,"is_corresponding":false},{"id":1571184,"name":"Leanna M Hernandez","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Neural Signatures of Autism Spectrum Disorders: Insights into Brain Network Dynamics","abstract":"Neuroimaging investigations of autism spectrum disorders (ASDs) have advanced our understanding of atypical brain function and structure, and have recently converged on a model of altered network-level connectivity. Traditional task-based functional magnetic resonance imaging (MRI) and volume-based structural MRI studies have identified widespread atypicalities in brain regions involved in social behavior and other core ASD-related behavioral deficits. More recent advances in MR-neuroimaging methods allow for quantification of brain connectivity using diffusion tensor imaging, functional connectivity, and graph theoretic methods. These newer techniques have moved the field toward a systems-level understanding of ASD etiology, integrating functional and structural measures across distal brain regions. Neuroimaging findings in ASD as a whole have been mixed and at times contradictory, likely due to the vast genetic and phenotypic heterogeneity characteristic of the disorder. Future longitudinal studies of brain development will be crucial to yield insights into mechanisms of disease etiology in ASD sub-populations. Advances in neuroimaging methods and large-scale collaborations will also allow for an integrated approach linking neuroimaging, genetics, and phenotypic data.","is_dataset_classified":null,"base_score":5.003946305945459,"endowment":5.003946305945459,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25011468","pmcid":"PMC4262896","openalex_id":"https://openalex.org/W1985486578","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"F31 MH093999","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM008042","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"2P50 HD055784 NIH- NICHD","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"5T32 MH073526-08 NIH","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"P50 HD055784","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"U54 HD087101","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"F31 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TDM","oa_locations":[{"url":"https://www.nature.com/articles/npp2014172.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/npp2014172.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/npp2014172.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/npp2014172","host_type":"publisher"},{"url":"https://doi.org/10.1038/npp.2014.172","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25011468","host_type":"repository"},{"url":"https://escholarship.org/uc/item/9jv7m7vm","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4262896","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/npp.2014.172","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/npp.2014.172","host_type":""}],"fields_of_study":["Autism Spectrum Disorder Research","Functional Brain Connectivity Studies","Advanced Neuroimaging Techniques and Applications","03 medical and health sciences","0302 clinical 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