{"doi":"10.1038/npg.els.0003304","title":"Chromatin Remodelling and Histone Modification in Transcription Regulation","abstract":"<jats:title>Abstract</jats:title>\n          <jats:p>The eukaryotic genome is assembled into chromatin, localized alterations of which are a major feature of gene control pathways. A wide variety of dedicated enzymatic complexes are targeted by particular transcriptional regulators to specific loci in the genome and remodel the structure of chromatin via energy‐dependent disruption of histone–DNA contacts and covalent modification of histones, both with major regulatory consequences.</jats:p>","journal":"Encyclopedia of Life Sciences","year":2001,"id":22749,"datarank":0.41722350123768237,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.1484595808534741,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.1484595808534741,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":5,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":114998,"name":"Alan P Wolffe","orcid":null,"position":1,"is_corresponding":false},{"id":114997,"name":"Fyodor D Urnov","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24259432","pmcid":null,"openalex_id":"https://openalex.org/W1903500145","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1038/npg.els.0003304","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1038/npg.els.0003304","host_type":"publisher"},{"url":"https://doi.org/10.1038/npg.els.0003304","host_type":"journal"}],"fields_of_study":["Genomics and Chromatin Dynamics","Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Cancer-related gene regulation","Chemistry","Biology"],"mesh_terms":[],"keywords":["Chromatin","Histone","Histone-modifying enzymes","Chromatin remodeling","ChIA-PET","Histone code","Cell biology","Biology","Scaffold/matrix attachment region","Genetics","DNA","Nucleosome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T15:57:17.554400Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}