{"doi":"10.1038/npg.els.0003010","title":"Calorimetry","abstract":"<jats:title>Abstract</jats:title>\n          <jats:p>In isothermal titration calorimetry, the heat produced or absorbed when a ligand binds to a biological macromolecule is measured and is used to characterize the energetics of the interaction. All of the thermodynamic quantities that characterize the binding reaction can be determined, and additional information on changes in protonation, and thus pH dependence, can also be studied.</jats:p>","journal":"Encyclopedia of Life Sciences","year":2001,"id":31983,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":170247,"name":"Kenneth P Murphy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24523987","pmcid":null,"openalex_id":"https://openalex.org/W4237305860","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1038/npg.els.0003010","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1038/npg.els.0003010","host_type":"publisher"},{"url":"https://doi.org/10.1038/npg.els.0003010","host_type":"journal"}],"fields_of_study":["thermodynamics and calorimetric analyses","Field-Flow Fractionation Techniques","ATP Synthase and ATPases Research"],"mesh_terms":[],"keywords":["Isothermal titration calorimetry","Calorimetry","Chemistry","Protonation","Energetics","Thermodynamics","Titration","Macromolecule","Isothermal process","Physical chemistry","Organic chemistry","Biochemistry","Physics","Ion"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T09:40:16.194338Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}