{"doi":"10.1038/npg.els.0001477","title":"Environmental Carcinogens and Mutagens","abstract":"<jats:title>Abstract</jats:title>\n          <jats:p>Environmental agents (chemicals, radiation and viruses) can be carcinogens (cancer‐causing substances) and mutagens (substances that alter DNA). The steps from mutagen/carcinogen to tumour involve mutagen/carcinogen activation by metabolism, reaction with DNA to give a DNA adduct and DNA replication of the adduct, resulting in a mutation; a mutation in a cancer gene may result in enhanced growth potential, and ultimately in tumour growth.</jats:p>","journal":"Encyclopedia of Life Sciences","year":2003,"id":19150,"datarank":0.4683590237305591,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.2604148695625755,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.2604148695625755,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":130639,"name":"Edward L Loechler","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21071399","pmcid":null,"openalex_id":"https://openalex.org/W1494228514","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2017,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1038/npg.els.0001477","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1038/npg.els.0001477","host_type":"publisher"},{"url":"https://doi.org/10.1038/npg.els.0001477","host_type":"journal"}],"fields_of_study":["Carcinogens and Genotoxicity Assessment","DNA Repair Mechanisms","Plant Genetic and Mutation Studies","Biology","Environmental Science","Medicine"],"mesh_terms":[],"keywords":["Carcinogen","Mutagen","DNA","Mutagenesis","Chemistry","DNA adduct","DNA damage","Adduct","DNA repair","Genetics","Mutation","Biology","Gene","Cancer research","Organic chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-04T02:14:18.594800Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}