{"doi":"10.1038/nn1661","title":"CREB modulates excitability of nucleus accumbens neurons","abstract":null,"journal":"Nature Neuroscience","year":2006,"id":602211,"datarank":0.882498358273242,"base_score":5.883322388488279,"endowment":5.883322388488279,"self_citation_contribution":0.882498358273242,"citation_network_contribution":0.0,"self_endowment_contribution":0.882498358273242,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":358,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1492655,"name":"Thomas Green","orcid":"0000-0003-2272-9567","position":1,"is_corresponding":false},{"id":1544383,"name":"Daniel Saal","orcid":null,"position":2,"is_corresponding":false},{"id":1544384,"name":"Helene Marie","orcid":null,"position":3,"is_corresponding":false},{"id":1544385,"name":"Rachael Neve","orcid":null,"position":4,"is_corresponding":false},{"id":136097,"name":"Eric J Nestler","orcid":null,"position":5,"is_corresponding":false},{"id":1544386,"name":"Robert C Malenka","orcid":null,"position":6,"is_corresponding":false},{"id":402647,"name":"Yan Dong","orcid":"0000-0003-1622-5354","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CREB modulates excitability of nucleus accumbens neurons","abstract":"Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.","is_dataset_classified":null,"base_score":5.883322388488279,"endowment":5.883322388488279,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16520736","pmcid":null,"openalex_id":"https://openalex.org/W2057855503","authors":[],"funders":[],"total_grants":0,"fwci":7.7885,"citation_percentile":0.98751959,"influential_citations":0,"citation_trend":[{"year":2012,"count":16},{"year":2013,"count":21},{"year":2014,"count":18},{"year":2015,"count":12},{"year":2016,"count":19},{"year":2017,"count":16},{"year":2018,"count":17},{"year":2019,"count":17},{"year":2020,"count":22},{"year":2021,"count":10},{"year":2022,"count":15},{"year":2023,"count":14},{"year":2024,"count":17},{"year":2025,"count":17},{"year":2026,"count":4}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/nn1661.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nn1661","host_type":"publisher"},{"url":"https://doi.org/10.1038/nn1661","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16520736","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neurotransmitter Receptor Influence on Behavior","Ion channel regulation and function","Animals","Calcium Channel Blockers","Cocaine","Cyclic AMP Response Element-Binding Protein","Dopamine Uptake Inhibitors","Motor Activity","Neurons","Nucleus Accumbens","Patch-Clamp Techniques","Potassium Channel Blockers","Potassium Channels, Inwardly Rectifying","Rats","Sodium Channel Blockers"],"mesh_terms":["Animals","Calcium Channel Blockers","Cocaine","Motor Activity","Neurons","Nucleus Accumbens","Cyclic AMP Response Element-Binding Protein","Patch-Clamp Techniques","Dopamine Uptake Inhibitors","Potassium Channels, Inwardly Rectifying","Potassium Channel Blockers","Sodium Channel Blockers","Rats"],"keywords":["CREB","Nucleus accumbens","Medium spiny neuron","Neuroscience","Chemistry","Cyclic AMP Response Element-Binding Protein","Basal ganglia","Biology","Central nervous system","Transcription factor","Biochemistry","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T18:40:41.211140Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}