{"doi":"10.1038/nn.4624","title":"Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells","abstract":null,"journal":"Nature Neuroscience","year":2017,"id":607868,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":273539,"name":"Jason Tucciarone","orcid":"0000-0002-6053-2952","position":1,"is_corresponding":false},{"id":851583,"name":"Nancy Padilla-Coreano","orcid":"0000-0001-9293-2697","position":2,"is_corresponding":false},{"id":143368,"name":"Miao He","orcid":"0000-0002-9918-3729","position":3,"is_corresponding":false},{"id":1560949,"name":"Joshua A Gordon","orcid":null,"position":4,"is_corresponding":false},{"id":58936,"name":"Z. Josh Huang","orcid":"0000-0003-0592-028X","position":5,"is_corresponding":false},{"id":554389,"name":"Jiangteng Lu","orcid":"0000-0001-6233-4266","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells","abstract":"The neocortex comprises multiple information processing streams mediated by subsets of glutamatergic pyramidal cells (PCs) that receive diverse inputs and project to distinct targets. How GABAergic interneurons regulate the segregation and communication among intermingled PC subsets that contribute to separate brain networks remains unclear. Here we demonstrate that a subset of GABAergic chandelier cells (ChCs) in the prelimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projecting to the basolateral amygdala (<sub>BLA</sub>PC) compared to those projecting to contralateral cortex (<sub>CC</sub>PC). These ChCs in turn receive preferential input from local and contralateral <sub>CC</sub>PCs as opposed to <sub>BLA</sub>PCs and BLA neurons (the prelimbic cortex-BLA network). Accordingly, optogenetic activation of ChCs rapidly suppresses <sub>BLA</sub>PCs and BLA activity in freely behaving mice. Thus, the exquisite connectivity of ChCs not only mediates directional inhibition between local PC ensembles but may also shape communication hierarchies between global networks.","is_dataset_classified":null,"base_score":4.844187086458591,"endowment":4.844187086458591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28825718","pmcid":"PMC5614838","openalex_id":"https://openalex.org/W2951384183","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"F30 MH097425","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH081968","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"Z99 MH999999","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH094705","title":null}],"total_grants":4,"fwci":5.007,"citation_percentile":0.96244368,"influential_citations":0,"citation_trend":[{"year":2017,"count":5},{"year":2018,"count":10},{"year":2019,"count":15},{"year":2020,"count":14},{"year":2021,"count":17},{"year":2022,"count":10},{"year":2023,"count":19},{"year":2024,"count":16},{"year":2025,"count":11},{"year":2026,"count":9}],"oa_status":"green","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5614838","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5614838","host_type":"repository"},{"url":"http://www.nature.com/articles/nn.4624.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nn.4624","host_type":"publisher"},{"url":"http://www.nature.com/doifinder/10.1038/nn.4624","host_type":"publisher"},{"url":"https://doi.org/10.1038/nn.4624","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28825718","host_type":"repository"},{"url":"https://repository.cshl.edu/id/eprint/35252/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5614838","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5614838?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neural dynamics and brain function","Photoreceptor and optogenetics research","Memory and Neural Mechanisms","Animals","Basolateral Nuclear Complex","Female","GABAergic Neurons","Interneurons","Male","Mice","Neocortex","Neural Inhibition","Neural Pathways","Prefrontal Cortex","Pyramidal Cells"],"mesh_terms":["Animals","Female","Interneurons","Male","Neural Inhibition","Neural Pathways","Prefrontal Cortex","Pyramidal Cells","Neocortex","Mice","GABAergic Neurons","Basolateral Nuclear Complex"],"keywords":["Neuroscience","Optogenetics","GABAergic","Neocortex","Inhibitory postsynaptic potential","Glutamatergic","Infralimbic cortex","Basolateral amygdala","Nerve net","Biology","Interneuron","Neuron","Cortex (anatomy)","Pyramidal cell","Amygdala","Prefrontal cortex","Glutamate receptor","Hippocampus","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:08:26.474593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}