{"doi":"10.1038/nn.2682","title":"Tuning arousal with optogenetic modulation of locus coeruleus neurons","abstract":null,"journal":"Nature Neuroscience","year":2010,"id":41079,"datarank":12.192744152139197,"base_score":6.927557906278317,"endowment":6.927557906278317,"self_citation_contribution":1.0391336859417477,"citation_network_contribution":11.15361046619745,"self_endowment_contribution":1.0391336859417477,"citer_contribution":11.15361046619745,"corpus_percentile":null,"corpus_rank":null,"citation_count":1019,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":198434,"name":"Ofer Yizhar","orcid":null,"position":1,"is_corresponding":false},{"id":198435,"name":"Sachiko Chikahisa","orcid":null,"position":2,"is_corresponding":false},{"id":198436,"name":"Hieu Nguyen","orcid":null,"position":3,"is_corresponding":false},{"id":197875,"name":"Antoine Adamantidis","orcid":null,"position":4,"is_corresponding":false},{"id":198437,"name":"Seiji Nishino","orcid":null,"position":5,"is_corresponding":false},{"id":169424,"name":"Karl Deisseroth","orcid":null,"position":6,"is_corresponding":false},{"id":198438,"name":"Luis de Lecea","orcid":null,"position":7,"is_corresponding":false},{"id":198433,"name":"Matthew E Carter","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.927557906278317,"endowment":6.927557906278317,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21037585","pmcid":"PMC3174240","openalex_id":"https://openalex.org/W2168415226","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH072525","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA021880","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA21880","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH083702","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH087592","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH87592","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"F31 MH083439","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"F31MH83439","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH83702","title":null},{"funder_name":"National Institutes of Health","grant_id":"5F31MH083439-03","title":"The Role of Hypocretins in the Regulation of Stress and Arousal"},{"funder_name":"National Institutes of Health","grant_id":"5R01MH072525-04","title":"Role of hypocretin/histamine in Narcolepsy/EDS disorders"}],"total_grants":11,"fwci":11.893,"citation_percentile":0.99344672,"influential_citations":14,"citation_trend":[{"year":2012,"count":36},{"year":2013,"count":44},{"year":2014,"count":47},{"year":2015,"count":67},{"year":2016,"count":62},{"year":2017,"count":53},{"year":2018,"count":84},{"year":2019,"count":68},{"year":2020,"count":75},{"year":2021,"count":84},{"year":2022,"count":73},{"year":2023,"count":85},{"year":2024,"count":95},{"year":2025,"count":92},{"year":2026,"count":32}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174240","host_type":"GREEN"},{"url":"http://www.nature.com/articles/nn.2682.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nn.2682","host_type":"publisher"},{"url":"https://doi.org/10.1038/nn.2682","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21037585","host_type":"repository"},{"url":"https://boris.unibe.ch/117261/","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3174240","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3174240","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3174240?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc3174240?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.7892/boris.117261","host_type":""},{"url":"http://dx.doi.org/10.1038/nn.2682","host_type":""},{"url":"https://dx.doi.org/10.1038/nn.2682","host_type":""}],"fields_of_study":["Photoreceptor and optogenetics research","Memory and Neural Mechanisms","Sleep and Wakefulness Research","Medicine","Biology","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Animals","Arousal","Gene Knock-In Techniques","Locus Coeruleus","Male","Mice","Mice, Inbred C57BL","Mice, Transgenic","Neurons","Photic Stimulation","Sleep Stages"],"mesh_terms":["Animals","Arousal","Locus Coeruleus","Male","Mice, Inbred C57BL","Mice, Transgenic","Neurons","Photic Stimulation","Sleep Stages","Mice","Gene Knock-In Techniques"],"keywords":["Locus coeruleus","Optogenetics","Arousal","Neuroscience","Wakefulness","Stimulation","Tonic (physiology)","Psychology","Electroencephalography","Central nervous system","Male","Neurons","Mice, Transgenic","Article","Mice, Inbred C57BL","Mice","Animals","Gene Knock-In Techniques","Sleep Stages","Photic Stimulation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.16680108.v1","title":"Additional file 1 of Associations between locus coeruleus integrity and nocturnal awakenings in the context of Alzheimer’s disease plasma biomarkers: a 7T MRI study","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.16680108","title":"Additional file 1 of Associations between locus coeruleus integrity and nocturnal awakenings in the context of Alzheimer’s disease plasma biomarkers: a 7T MRI study","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T20:54:30.070219Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}