{"doi":"10.1038/nmicrobiol.2016.124","title":"Probing the metabolic heterogeneity of live Euglena gracilis with stimulated Raman scattering microscopy","abstract":null,"journal":"Nature Microbiology","year":2016,"id":681133,"datarank":0.7312795984801728,"base_score":4.875197323201151,"endowment":4.875197323201151,"self_citation_contribution":0.7312795984801728,"citation_network_contribution":0.0,"self_endowment_contribution":0.7312795984801728,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":130,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":64866,"name":"Yuta Suzuki","orcid":"0000-0002-8528-9418","position":1,"is_corresponding":false},{"id":1779607,"name":"Osamu Iwata","orcid":null,"position":2,"is_corresponding":false},{"id":958480,"name":"Ayaka Nakashima","orcid":"0000-0001-7474-406X","position":3,"is_corresponding":false},{"id":1779608,"name":"Takuro Ito","orcid":null,"position":4,"is_corresponding":false},{"id":577307,"name":"Misa Hirose","orcid":"0000-0002-8909-4693","position":5,"is_corresponding":false},{"id":1779609,"name":"Ryota Domon","orcid":null,"position":6,"is_corresponding":false},{"id":1779610,"name":"Mai Sugawara","orcid":null,"position":7,"is_corresponding":false},{"id":1779611,"name":"Norimichi Tsumura","orcid":null,"position":8,"is_corresponding":false},{"id":1091675,"name":"Hiroshi Watarai","orcid":"0000-0001-5701-0806","position":9,"is_corresponding":false},{"id":1204178,"name":"Tomoyoshi Shimobaba","orcid":"0000-0003-1638-7695","position":10,"is_corresponding":false},{"id":958481,"name":"Kengo Suzuki","orcid":"0000-0001-5692-6169","position":11,"is_corresponding":false},{"id":642721,"name":"Keisuke Goda","orcid":"0000-0001-6302-6038","position":12,"is_corresponding":false},{"id":1779612,"name":"Yasuyuki Ozeki","orcid":null,"position":13,"is_corresponding":false},{"id":1779606,"name":"Yoshifumi Wakisaka","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Probing the metabolic heterogeneity of live Euglena gracilis with stimulated Raman scattering microscopy","abstract":"Understanding metabolism in live microalgae is crucial for efficient biomaterial engineering, but conventional methods fail to evaluate heterogeneous populations of motile microalgae due to the labelling requirements and limited imaging speeds. Here, we demonstrate label-free video-rate metabolite imaging of live Euglena gracilis and statistical analysis of intracellular metabolite distributions under different culture conditions. Our approach provides further insights into understanding microalgal heterogeneity, optimizing culture methods and screening mutant microalgae.","is_dataset_classified":null,"base_score":4.875197323201151,"endowment":4.875197323201151,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27670110","pmcid":null,"openalex_id":"https://openalex.org/W2476246726","authors":[],"funders":[],"total_grants":0,"fwci":19.957,"citation_percentile":0.99160271,"influential_citations":2,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":11},{"year":2018,"count":15},{"year":2019,"count":19},{"year":2020,"count":15},{"year":2021,"count":22},{"year":2022,"count":18},{"year":2023,"count":8},{"year":2024,"count":8},{"year":2025,"count":11},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://www.nature.com/articles/nmicrobiol2016124.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/nmicrobiol2016124","host_type":"publisher"},{"url":"https://doi.org/10.1038/nmicrobiol.2016.124","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27670110","host_type":"repository"}],"fields_of_study":["Spectroscopy Techniques in Biomedical and Chemical Research","Advanced Fluorescence Microscopy Techniques","Cell Image Analysis Techniques","Chemistry","Medicine","Environmental Science","Biology"],"mesh_terms":["Animals","Euglena gracilis","Scattering, Radiation","Spectrum Analysis, Raman","Water","Microscopy, Video","Optical Imaging"],"keywords":["Euglena gracilis","Metabolite","Live cell imaging","Biology","Intracellular","Video microscopy","Euglena","Cell biology","Biophysics","Biochemistry","Cell","Chloroplast","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T17:00:47.673972Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}