{"doi":"10.1038/nmeth.3799","title":"Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases","abstract":"Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type- and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease-associated genetic variants--including variants that do not reach genome-wide significance--often perturb regulatory modules that are highly specific to disease-relevant cell types or tissues. Our resource opens the door to systematic analysis of regulatory programs across hundreds of human cell types and tissues (http://regulatorycircuits.org).","journal":"Nature Methods","year":2016,"id":7040,"datarank":8.812529335106936,"base_score":5.918893854273146,"endowment":5.918893854273146,"self_citation_contribution":0.887834078140972,"citation_network_contribution":7.924695256965964,"self_endowment_contribution":0.887834078140972,"citer_contribution":7.924695256965964,"corpus_percentile":76.32221318144833,"corpus_rank":292,"citation_count":381,"citer_count":193,"citers_with_citation_signal":193,"citers_with_endowment":193,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7796,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2016-03-07","algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":63917,"name":"David Lamparter","orcid":"0000-0002-9216-8825","position":1,"is_corresponding":false},{"id":4950,"name":"Richard Sandstrom","orcid":"0000-0002-3356-1547","position":2,"is_corresponding":false},{"id":14693,"name":"Sharon L. R. Kardia","orcid":"0000-0002-9853-3379","position":3,"is_corresponding":false},{"id":5243,"name":"Zoltán Kutalik","orcid":"0000-0001-8285-7523","position":4,"is_corresponding":false},{"id":21856,"name":"Sven Bergmann","orcid":"0000-0002-6785-9034","position":5,"is_corresponding":false},{"id":30779,"name":"Daniel Marbach","orcid":"0000-0002-6686-9249","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}