{"doi":"10.1038/nmeth.3176","title":"Fast and sensitive protein alignment using DIAMOND","abstract":"The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. We introduce DIAMOND, an open-source algorithm based on double indexing that is 20,000 times faster than BLASTX on short reads and has a similar degree of sensitivity.","journal":"Nature Methods","year":2014,"id":7376,"datarank":20.161937051113902,"base_score":9.602382459752207,"endowment":9.602382459752207,"self_citation_contribution":1.4403573689628313,"citation_network_contribution":18.72157968215107,"self_endowment_contribution":1.4403573689628313,"citer_contribution":18.72157968215107,"corpus_percentile":97.0,"corpus_rank":575,"citation_count":14799,"citer_count":195,"citers_with_citation_signal":195,"citers_with_endowment":195,"datacite_reuse_total":0,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2014-11-17","authors":[{"id":65856,"name":"Chao Xie","orcid":null,"position":1,"is_corresponding":false},{"id":4059,"name":"Daniel H. Huson","orcid":"0000-0002-2961-604X","position":2,"is_corresponding":false},{"id":65855,"name":"Benjamin Buchfink","orcid":"0000-0001-7658-731X","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}