{"doi":"10.1038/nmeth.2604","title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","abstract":"Amplified marker-gene sequences can be used to understand microbial community structure, but they suffer from a high level of sequencing and amplification artifacts. The UPARSE pipeline reports operational taxonomic unit (OTU) sequences with ≤1% incorrect bases in artificial microbial community tests, compared with >3% incorrect bases commonly reported by other methods. The improved accuracy results in far fewer OTUs, consistently closer to the expected number of species in a community.","journal":"Nature Methods","year":2013,"id":8537,"datarank":18.70363587262538,"base_score":9.746014693711563,"endowment":9.746014693711563,"self_citation_contribution":1.4619022040567347,"citation_network_contribution":17.241733668568646,"self_endowment_contribution":1.4619022040567347,"citer_contribution":17.241733668568646,"corpus_percentile":97.3,"corpus_rank":410,"citation_count":17085,"citer_count":197,"citers_with_citation_signal":197,"citers_with_endowment":197,"datacite_reuse_total":0,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2013-08-18","authors":[{"id":29074,"name":"R. C. Edgar","orcid":"0000-0001-7355-2541","position":1,"is_corresponding":false}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}