{"doi":"10.1038/nm.4443","title":"Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation","abstract":null,"journal":"Nature Medicine","year":2018,"id":641498,"datarank":0.9756432260304969,"base_score":6.504288173536645,"endowment":6.504288173536645,"self_citation_contribution":0.9756432260304969,"citation_network_contribution":0.0,"self_endowment_contribution":0.9756432260304969,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":667,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1667986,"name":"Jing L Guo","orcid":null,"position":1,"is_corresponding":false},{"id":1667987,"name":"Jennifer D McBride","orcid":null,"position":2,"is_corresponding":false},{"id":440011,"name":"Sneha Narasimhan","orcid":"0000-0002-1665-9681","position":3,"is_corresponding":false},{"id":486547,"name":"Hyesung Kim","orcid":"0000-0002-5560-8481","position":4,"is_corresponding":false},{"id":261463,"name":"Lakshmi Changolkar","orcid":null,"position":5,"is_corresponding":false},{"id":1238484,"name":"Bin Zhang","orcid":"0000-0003-2606-5825","position":6,"is_corresponding":false},{"id":1667988,"name":"Ronald J Gathagan","orcid":null,"position":7,"is_corresponding":false},{"id":1667989,"name":"Cuiyong Yue","orcid":null,"position":8,"is_corresponding":false},{"id":1667990,"name":"Christopher Dengler","orcid":null,"position":9,"is_corresponding":false},{"id":507462,"name":"Anna Stieber","orcid":null,"position":10,"is_corresponding":false},{"id":1524778,"name":"Magdalena Nitla","orcid":null,"position":11,"is_corresponding":false},{"id":1667991,"name":"Douglas A Coulter","orcid":null,"position":12,"is_corresponding":false},{"id":376729,"name":"Ted Abel","orcid":"0000-0003-2423-4592","position":13,"is_corresponding":false},{"id":1667992,"name":"Kurt R Brunden","orcid":null,"position":14,"is_corresponding":false},{"id":1667993,"name":"John Q Trojanowski","orcid":null,"position":15,"is_corresponding":false},{"id":1667994,"name":"Virginia M-Y Lee","orcid":null,"position":16,"is_corresponding":false},{"id":260091,"name":"Zhuohao He","orcid":"0000-0003-1505-8750","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation","abstract":"Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pathological tau (AD-tau) into Aβ plaque-bearing mouse models that do not overexpress tau, we recapitulated the formation of three major types of AD-relevant tau pathologies: tau aggregates in dystrophic neurites surrounding Aβ plaques (NP tau), AD-like neurofibrillary tangles (NFTs) and neuropil threads (NTs). These distinct tau pathologies have different temporal onsets and functional consequences on neural activity and behavior. Notably, we found that Aβ plaques created a unique environment that facilitated the rapid amplification of proteopathic AD-tau seeds into large tau aggregates, initially appearing as NP tau, which was followed by the formation and spread of NFTs and NTs, likely through secondary seeding events. Our study provides insights into a new multistep mechanism underlying Aβ plaque-associated tau pathogenesis.","is_dataset_classified":null,"base_score":6.504288173536645,"endowment":6.504288173536645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29200205","pmcid":"PMC5760353","openalex_id":"https://openalex.org/W2772451653","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"P01 AG017586","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"U54 HD086984","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P01 AG017628","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P30 AG010124","title":null},{"funder_name":"National Institutes of Health","grant_id":"5P01AG017628-13","title":"Mouse Behavioral Assessment and Breeding Core"},{"funder_name":"National Institutes of Health","grant_id":"5P01AG017586-18","title":"Frontotemporal Dementias: Genotypes and Phenotypes"},{"funder_name":"National Institutes of Health","grant_id":"3P30AG010124-28S1","title":"Alzheimer's Disease Core Center - Neuroimaging Core I"}],"total_grants":7,"fwci":26.0219,"citation_percentile":0.99799599,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2018,"count":36},{"year":2019,"count":50},{"year":2020,"count":94},{"year":2021,"count":106},{"year":2022,"count":97},{"year":2023,"count":75},{"year":2024,"count":108},{"year":2025,"count":70},{"year":2026,"count":30}],"oa_status":"green","license":"Springer Nature TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760353","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760353","host_type":"repository"},{"url":"https://www.nature.com/articles/nm.4443.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/nm.4443","host_type":"publisher"},{"url":"http://www.nature.com/doifinder/10.1038/nm.4443","host_type":"publisher"},{"url":"https://doi.org/10.1038/nm.4443","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29200205","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC5760353","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc5760353?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1038/nm.4443","host_type":""}],"fields_of_study":["Alzheimer's disease research and treatments","Neuroinflammation and Neurodegeneration Mechanisms","Dementia and Cognitive Impairment Research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Alzheimer Disease","Amyloid beta-Peptides","Animals","Axons","Hippocampus","Humans","Mice","Neurites","Neurofibrillary Tangles","tau Proteins"],"mesh_terms":["Alzheimer Disease","Animals","Axons","Hippocampus","Humans","Amyloid beta-Peptides","Neurites","Neurofibrillary Tangles","tau Proteins","Mice"],"keywords":["Senile plaques","Tau protein","Neuroscience","Tauopathy","Tau pathology","Neurite","Pathology","Alzheimer's disease","Amyloid (mycology)","Extracellular","Pathogenesis","Neuropil","Intracellular","Chemistry","Biology","Neurodegeneration","Medicine","Cell biology","Disease","Central nervous system","Biochemistry","Mice","Amyloid beta-Peptides","Alzheimer Disease","Neurites","Animals","Humans","Neurofibrillary Tangles","tau Proteins","Hippocampus","Axons"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T18:27:04.987233Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}